Zalox (sertraline in the form of sertraline hydrochloride) capsules 50 mg. №30

Description

Zalox (sertraline in the form of sertraline hydrochloride) capsules 50 mg. №30

Composition

active substance: sertraline in the form of sertraline hydrochloride;

1 capsule contains sertraline 50 mg in the form of sertraline hydrochloride;

Excipients: lactose anhydrous, corn starch, sodium lauryl sulfate, magnesium stearate;

the composition of the capsule shell: gelatin, quinoline yellow dye (E 104), yellow dye FCF (E 110), titanium dioxide (E 171).

Dosage form

Capsules.

Main physical and chemical properties: Conisnap # 4 hard gelatin capsules are filled with white or almost white powder. Sertraline is coated with a white capsule, followed by 50 mg. “Sertraline” is emphasized. “P” is applied to the cap of the yellow capsule. Black inscriptions.

Pharmacotherapeutic group

Antidepressants. Selective inhibitors of neuronal serotonin reuptake.

ATX N06A B06.

Pharmacological properties

Zalox is an antidepressant that is widely used in psychiatry and has the ability to suppress the expression of norepinephrine and serotonin receptors in the brain.
Indications for use
Zalox is used to prevent and treat depressive states: depressive psychosis, which is accompanied by feelings of anxiety, manic manifestations of mental disorders. Prophylactic antidepressant is also prescribed to prevent the recurrence of depressive relapses and illness, obsessive-compulsive disorder and obsessive-compulsive disorder, agoraphobia (panic fear of open spaces), post-traumatic stress disorder, and other manifestations of psychosis.

Indication:

• major depressive episodes. Prevention of recurrence of major depressive episodes;
• panic disorders with or without agoraphobia;
• obsessive-compulsive disorder (OCD) in adults and children 6-17 years;
• social anxiety disorder;
• post-traumatic stress disorder (PTSD).

Contraindications

Zalox has contraindications to use: hypersensitivity reactions to the components that are part of this tool, the use of concomitant biologically active substances that have the ability to inhibit the enzyme monoamine oxidase. Also children, except for children older than six years, who have obsessive-compulsive disorders.

Use during pregnancy and breastfeeding

The use of Zalox capsules for pregnant women and during breastfeeding is contraindicated. An exception is the doctor’s recommendation in cases where the expected benefits of taking this drug outweigh the possible risks.

Method of application and dose

The use of the drug Zalox capsules for the treatment of depressive states in adults and children over 13 years, starting with a dose of 50 mg per day. In nervous disorders, which are accompanied by a feeling of anxiety, the daily dose is 25 mg, if necessary on the advice of a doctor, the dose is increased to 50 mg. Children aged 6-12 years: the initial dose is 25 mg once a day. After 7 days, the daily dose can be increased to 50 mg.
If after a week of treatment there is no positive response, then the doctor increases the dosage, but the dose should not exceed 200 ml per day. However, it takes a long time, about four weeks, to improve your health.
The dosage during long-term treatment with Zalox capsules should be kept at the minimum effective level, followed by adjustment depending on the patient’s condition.
Withdrawal of the drug should be carried out gradually, to avoid withdrawal syndrome, over 7-14 days.
The capsules should be taken once a day in the morning or evening, at the same hour, regardless of food intake, washed down with water without chewing.

Overdose

Signs of Zalox capsules overdose are: drowsiness, tachycardia and agitation, nausea, dizziness, vomiting, tremor, in rare cases, coma is possible.
If these symptoms occur, maintenance therapy should be performed, which includes gastric lavage, administration of activated charcoal, use of laxatives, monitoring of cardiac activity and other systemic physiological parameters.

Side effects

The use of the drug Zalox can cause quite a number of side effects: pharyngitis, diverticulitis, upper respiratory tract infections, gastroenteritis, rhinitis, lymphadenopathy, otitis media, thrombocytopenia, leukopenia, anaphylactoid and allergic reactions, aperapentine syndrome or inadequacy. hypothyroidism, hypoglycemia, hypercholesterolemia, hyponatremia. Hyperglycaemia and diabetes mellitus, hyperhidrosis, ejaculatory disorders, periorbital edema, vaginal bleeding, menorrhagia, sexual and erectile dysfunction in women, gynecomastia, atrophic vulvovaginitis, necropalatine galactoma, genital discharge have also been reported.
Also possible: purpura, dry skin, cold sweat, hives, rashes and dermatitis, atypical skin odor, hair texture pathology, angioneurotic edema, photosensitization, facial edema, itching, nocturia, skin reactions, urinary retention and pollakiuria, polyuria, urinary incontinence oliguria, difficulty starting to urinate and urinary incontinence. Increased fatigue and general malaise, chest pain, chills, asthenia.
Taking the drug can cause: insomnia, depersonalization, depression and nightmares, agitation, anxiety, nervousness, bruxism, hallucinations, decreased libido, euphoria, abnormal thinking and apathy, drug addiction, aggression, psychotic disorder or paranoid, paranoid, behavior, paronymy and somnambulism. Also diarrhea, dry mouth, nausea, abdominal pain, vomiting, dyspepsia, constipation and flatulence, esophagitis, hemorrhoids, dysphagia, hypersalivation, stomatitis.
Side effects also include: dizziness, headache, drowsiness, paresthesia, hypertension, tremor, dysgeusia, convulsions, impaired attention, involuntary muscle contractions, hyperkinesia, incoordination, amnesia, impaired speech, hypoaesthesia, progressive dizziness choreoathetosis, hyperesthesia, dyskinesia, sensory disturbances, movement disorders, syncope. Possible liver dysfunction and liver failure, in rare cases, death, fulminant and necrotic hepatitis, myalgia, cholestatic jaundice, osteoarthritis.
Other side effects with Zalox are also possible: visual disturbances, tearing disorders, glaucoma, scotoma, photophobia, diplopia, hyphema, visual disturbances and ringing in the ears, mydriasis, palpitations.