Zovirax (acyclovir) tablets 200 mg. №25

Description

Zovirax (acyclovir) tablets 200 mg. №25

Composition

active substance: acyclovir,

1 tablet contains acyclovir 200 mg;

Excipients: lactose monohydrate, microcrystalline cellulose, sodium starch glycolate, povidone K 30, magnesium stearate.

Dosage form

White, round, biconvex tablets marked GXCL3 on one side.

Pharmacotherapeutic group

Antiviral drugs for systemic use.

ATX code J05A B01.

Pharmacological properties

Zovirax (acyclovir) is a synthetic purine nucleoside analogue with in vivo and in vitro inhibitory activity against human herpes virus, including herpes simplex virus type I and II, chickenpox and shingles virus, Epstein-Barr virus and cytomegalovirus. In cell culture, acyclovir is most active against herpes simplex virus type I and then, in decreasing activity, against herpes simplex virus type II, chickenpox and shingles virus, Epstein-Barr virus and cytomegalovirus.

Indication:

• treatment of viral infections of the skin and mucous membranes caused by the herpes simplex virus, including primary and recurrent genital herpes;
• suppression (prevention of recurrence) of infections caused by the herpes simplex virus in patients with normal immunity;
• prevention of herpes simplex virus infections in immunodeficient patients;
• treatment of infections caused by Varicella zoster virus (chickenpox and shingles).

Contraindication

Hypersensitivity to acyclovir, valacyclovir or to other components of the drug.

Method of application and dosage

The tablet Zovirax (acyclovir) should be taken whole with water. Adequate hydration should be maintained with high doses of acyclovir.

Adults

Treatment of infections caused by the herpes simplex virus

For the treatment of herpes simplex virus infections, Zovirax 200 mg tablets should be taken 5 times a day at approximately 4-hour intervals, except at night.

Treatment should last 5 days, but in case of severe primary infection it can be continued.

For patients with severe immunodeficiency (eg after bone marrow transplantation) or for patients with reduced intestinal absorption, the dose may be doubled to 400 mg or the appropriate dose may be administered intravenously.

Treatment should be started as early as possible after the onset of infection. In case of recurrent herpes, it is best to start treatment in the prodromal period or after the first signs of skin lesions.

Prevention of recurrence (suppressive therapy) of infections caused by herpes simplex virus

In patients with normal immunity, Zovirax 200 mg tablets are taken 4 times a day at approximately 6-hour intervals to prevent recurrence of herpes simplex virus infections.

For convenience, most patients may take 400 mg of Zovirax twice daily at approximately 12-hour intervals.

Treatment will be effective even after reducing the dose of Zovirax tablets to 200 mg, taken 3 times a day with an 8-hour interval or even 2 times a day with a 12-hour interval.

In some patients, radical improvement is observed after taking a total daily dose of Zovirax 800 mg.

Zovirax therapy should be discontinued periodically at intervals of 6 to 12 months to monitor for possible changes in the natural course of the disease.

Prevention of infections caused by herpes simplex virus

To prevent infections caused by the herpes simplex virus, patients with immunodeficiency Zovirax 200 mg tablets should be taken 4 times a day at approximately 6-hour intervals. For patients with severe immunodeficiency (eg after bone marrow transplantation) or for patients with reduced intestinal absorption, the dose may be doubled to 400 mg or the appropriate dose may be administered intravenously.

The duration of prevention depends on the length of the risk period.

Treatment of chickenpox and shingles

For the treatment of infections caused by the chickenpox virus and shingles, Zovirax 800 mg tablets should be taken 5 times a day at approximately 4-hour intervals, except at night. The treatment should last 7 days.

In patients with severe immunodeficiency (eg, after bone marrow transplantation) or in patients with reduced intestinal absorption, it is best to use intravenous administration.

Treatment should be started as early as possible after the onset of the disease, the result will be better if treatment is started immediately after the rash.

Children

For the treatment of herpes simplex virus infections and the prevention of herpes simplex virus infections in children with immunodeficiency over 2 years of age, adult doses can be used. For the treatment of chickenpox in children over 6 years of age is prescribed 800 mg of Zovirax 4 times a day, children aged 2 to 6 years can receive 400 mg of Zovirax 4 times a day. The duration of treatment is 5 days.

More precisely, a single dose of the drug can be calculated by the child’s body weight as 20 mg / kg body weight (not to exceed 800 mg) Zovirax 4 times a day.

There are no specific data from the use of Zovirax (acyclovir) in the prevention (prevention) of infections caused by herpes simplex virus or in the treatment of herpes simplex virus infections in children with normal immunity.

Zovirax, a lyophilisate for infusion solution, is used to treat herpes virus infections in newborns and children under 3 months of age.

Overdose

Acyclovir is only partially absorbed from the gastrointestinal tract. There have been cases of unintentional ingestion of patients up to 20 g of acyclovir without toxic effects. Accidental re-overdose of oral acyclovir for several days may cause gastrointestinal (such as nausea and vomiting) and neurological symptoms (headache and confusion).

Side effects:

• mental disorders and disorders of the nervous system: headache, dizziness;
• gastrointestinal system: nausea, vomiting, diarrhea, abdominal pain;
• skin and subcutaneous tissue disorders: itching, rash (including photosensitivity).