Description
Diclofenak (Diclofenac) Gel 1% 50 g
Ingredients:
- Diclofenac Sodium
- Carbomer
- Isopropyl Alcohol
- Propylene Glycol
- Purified Water
Mechanism of Action:
Diclofenac gel contains diclofenac, which inhibits the enzyme cyclooxygenase, leading to a reduction in prostaglandin production. This mechanism helps alleviate pain and inflammation at the application site.
Pharmacological Properties:
Diclofenac gel exerts analgesic and anti-inflammatory effects by targeting the cyclooxygenase enzyme pathway, thereby modulating the inflammatory response and reducing pain sensation.
Indications for Use:
Diclofenac gel is indicated for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Contraindications:
Avoid using Diclofenac gel if you have a known allergy to diclofenac or any other components of the gel. Do not apply the gel on open wounds, mucous membranes, or near the eyes.
Side Effects:
Common side effects of Diclofenac gel may include skin irritation, redness, or rash at the application site. Discontinue use if severe reactions occur and seek medical advice.
Usage Instructions:
Apply a thin layer of Diclofenac gel to the affected area 3-4 times daily and gently massage in. Do not cover with bandages. Wash hands after application to prevent inadvertent contact with eyes or mucous membranes.
Benefits Compared to Analogues:
Diclofenac gel offers localized pain relief with reduced systemic absorption compared to oral formulations, minimizing the risk of systemic side effects while targeting the specific site of inflammation.
Suitable Patient Groups:
Diclofenac gel is suitable for adults, including the elderly, for the management of pain and inflammation associated with various arthritic conditions. It is not recommended for children without medical supervision.
Storage and Shelf Life:
Store Diclofenac gel at room temperature away from moisture and heat. Check the expiration date on the packaging and do not use beyond the indicated shelf life.
Packaging Description:
Diclofenac gel is supplied in a tube containing 50g of 1% gel formulation. The packaging includes instructions for use and precautions to ensure safe application.
Clinical Evidence and Proven Effectiveness:
Studies have demonstrated the efficacy of topical diclofenac formulations such as Diclofenac gel in providing effective pain relief with reduced systemic exposure compared to oral forms. Research published in the Journal of Pain Research highlighted the pain-reducing and functional improvement effects of diclofenac gel in knee osteoarthritis patients.
Clinical trials have shown the efficacy of diclofenac gel in providing symptomatic relief in musculoskeletal conditions. A study in the Journal of Clinical Rheumatology indicated that diclofenac gel effectively reduced pain intensity in knee osteoarthritis patients.
