Description
Diclofenak Natrium (Diclofenac) Rectal Suppositories 0.05 g. №10
Composition
Active Ingredient: Diclofenac sodium 0.05 g per suppository.
Mechanism of Action
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. It functions by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins that contribute to pain and inflammation.
Pharmacological Properties
Diclofenac suppositories exert their effects by inhibiting prostaglandin synthesis, which leads to decreased inflammation, pain relief, and antipyresis.
Indications for Use
Diclofenac suppositories are indicated for the relief of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Contraindications
Do not use diclofenac suppositories if you:
- Have a history of allergic reactions to diclofenac or other NSAIDs.
- Are in the third trimester of pregnancy.
- Have active peptic ulcers or gastrointestinal bleeding.
Side Effects
Common side effects of diclofenac suppositories may include gastrointestinal discomfort, headache, and dizziness. It is advised to consult a healthcare provider if any adverse reactions occur.
Usage Instructions
For rectal use: Wash hands before and after use. Lie on your side and insert the suppository into the rectum. Follow the instructions provided by your healthcare provider.
Benefits Compared to Analogues
Diclofenac suppositories have demonstrated superior pain relief and anti-inflammatory efficacy compared to placebo in various musculoskeletal conditions, as supported by clinical studies.
Suitable Patient Groups
Diclofenac suppositories are suitable for adult patients. Consult a healthcare professional for personalized dosing and use in specific patient populations such as the elderly or individuals with renal impairment.
Storage and Shelf Life
Store the suppositories in a cool, dry place away from direct sunlight. Ensure they are kept out of reach of children. Check the packaging for the expiry date and do not use after the specified shelf life.
Packaging Description
The product is available in packs containing 10 diclofenac sodium rectal suppositories, each with a dosage of 0.05 g.
Clinical Evidence and Proven Effectiveness
Studies have demonstrated the efficacy of diclofenac in managing pain and inflammation associated with musculoskeletal conditions. Notably, research published in the Journal of Pain Research highlighted the superior pain relief provided by diclofenac suppositories compared to placebo in patients with osteoarthritis.
