Description
Dicloseif (Diclofenac) Suppositories 100 mg. №10
Composition
Active ingredient: Diclofenac sodium 100 mg.
Other ingredients: Hard fat.
Mechanism of Action
Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase (COX), thus reducing the production of prostaglandins. Prostaglandins are chemical mediators that play a key role in the inflammatory process, pain perception, and fever response.
Pharmacological Properties
Diclofenac possesses analgesic, anti-inflammatory, and antipyretic properties. By inhibiting prostaglandin synthesis, it helps alleviate pain, reduce inflammation, and lower fever.
Indications for Use
Dicloseif suppositories are indicated for the symptomatic treatment of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis in adult patients.
Contraindications
Avoid using Dicloseif suppositories if you:
- Have a history of hypersensitivity or allergic reactions to diclofenac or other NSAIDs.
- Are in the third trimester of pregnancy, as it may cause fetal harm.
- Currently have active peptic ulcers, gastrointestinal bleeding, or a history of these conditions.
Side Effects
Common side effects of diclofenac suppositories may include gastrointestinal disturbances, such as nausea, abdominal pain, and diarrhea. Other potential adverse reactions may involve skin reactions, headache, and dizziness. In rare cases, severe allergic reactions or gastrointestinal bleeding may occur.
Usage Instructions
For adults: Insert one suppository into the rectum once daily. It is essential to adhere to the prescribed dosage and not exceed the recommended frequency of administration. Prior to and following administration, ensure proper hand hygiene. Lie on your side with one leg bent and gently insert the suppository into the rectum. Remember to wash your hands thoroughly after use.
Benefits Compared to Analogues
Dicloseif suppositories offer a targeted delivery method that bypasses the gastrointestinal tract, potentially reducing the incidence of gastrointestinal side effects commonly associated with oral NSAIDs. This route of administration may enhance drug efficacy and provide localized relief to affected areas.
Suitable Patient Groups
Dicloseif suppositories are suitable for adult patients with rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis who may benefit from rectal administration. Consult a healthcare professional for appropriate use in specific patient populations, such as the elderly or individuals with gastrointestinal sensitivities.
Storage and Shelf Life
Store Dicloseif suppositories in a cool, dry place away from direct sunlight. Ensure proper sealing of the packaging to protect the product from moisture. Check the expiration date on the packaging and do not use the product beyond the stated shelf life.
Packaging Description
Dicloseif suppositories are typically packaged in blister packs to maintain product integrity and facilitate individual dosing. Each pack contains a specified number of suppositories for convenient use and storage.
Clinical Evidence and Proven Effectiveness
Studies have demonstrated the efficacy of diclofenac in managing pain and inflammation associated with various musculoskeletal disorders. Clinical trials have shown that diclofenac suppositories provide effective relief with a reduced risk of systemic side effects compared to oral administration. The targeted delivery mechanism of suppositories enhances drug concentration at the site of action, optimizing therapeutic outcomes.
