Description

Duodart (dutasteride/tamsulosin) Hard Capsules 0.5 mg/0.4 mg – Pack of 30

Composition

Duodart capsules contain 0.5 mg of dutasteride and 0.4 mg of tamsulosin hydrochloride. Dutasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT), while tamsulosin is an alpha-blocker that relaxes the muscles in the prostate and bladder neck.

Mechanism of Action

Dutasteride inhibits the enzyme 5-alpha reductase, reducing DHT levels and shrinking the prostate gland to relieve urinary symptoms. Tamsulosin relaxes prostate and bladder neck muscles, facilitating urination.

Pharmacological Properties

The combination of dutasteride and tamsulosin in Duodart effectively improves symptoms of benign prostatic hyperplasia (BPH) by reducing prostate volume, enhancing urinary flow, and decreasing the need for surgical intervention.

Indications for Use

Duodart is indicated for symptomatic BPH treatment in adult men with an enlarged prostate. It aids in improving urinary flow, reducing acute urinary retention risk, and decreasing the necessity for prostate surgery.

Contraindications

Avoid Duodart if allergic to dutasteride, tamsulosin, or any capsule ingredient. Contraindicated in women and children.

Side Effects

Common side effects include dizziness, decreased libido, and ejaculation disorders. Regular monitoring by a healthcare provider is essential.

Usage Instructions

Take one Duodart capsule daily with water. Adhere to prescribed dosage and consult a healthcare provider before altering it.

Benefits Compared to Analogues

Studies have shown that the dutasteride and tamsulosin combination in Duodart is more effective in BPH symptom improvement than individual medications. Research in the Journal of Urology demonstrated reduced prostate volume and improved urinary symptoms with this combination therapy.

Suitable Patient Groups

Duodart is suitable for adult men with symptomatic BPH. Consult a healthcare provider for dosing adjustments in special populations like the elderly.

Storage and Shelf Life

Store Duodart at recommended conditions and within the specified shelf life to maintain efficacy and safety.

Packaging Description

Duodart is available in packs containing 30 hard capsules for easy and convenient dosing.

Clinical Evidence and Proven Effectiveness

Clinical trials have demonstrated Duodart’s efficacy in improving urinary symptoms, reducing disease progression risk, and enhancing quality of life in men with BPH. Long-term studies confirm sustained benefits with continued use.