Description
Fosmural Granules for Oral Suspension 3g. Sachet №1
Ingredients:
Each sachet contains:
- Active ingredient: Fosmural 3g
- Excipients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, tutti-frutti flavor
Mechanism of Action:
Fosmural works by inhibiting bone resorption and promoting bone formation, leading to increased bone mineral density and reduced fracture risk. It is a bisphosphonate that specifically targets osteoclasts, the cells responsible for breaking down bone tissue.
Pharmacological Properties:
Fosmural is a potent bisphosphonate that selectively inhibits osteoclastic bone resorption without directly affecting the mineralization process.
Indications for Use:
Fosmural granules are indicated for the treatment of osteoporosis in postmenopausal women to improve bone mineral density and reduce the risk of fractures.
Contraindications:
Do not use Fosmural granules if you have a history of hypersensitivity to any of the ingredients. Patients with esophageal abnormalities that delay esophageal emptying should not use Fosmural due to the potential risk of esophageal irritation.
Side Effects:
Common side effects of Fosmural may include gastrointestinal disturbances such as dyspepsia, abdominal pain, and constipation. Rare but serious side effects may include osteonecrosis of the jaw and atypical femoral fractures.
Usage Instructions:
The recommended dosage for adults is one sachet daily, dissolved in a glass of water. The granules should be stirred well and consumed immediately. Do not chew the granules.
Benefits Compared to Analogues:
Fosmural has shown superior efficacy in improving bone mineral density and reducing fracture risk compared to other bisphosphonates. Its once-daily dosing regimen offers convenience and improved patient compliance.
Suitable Patient Groups:
Fosmural is suitable for postmenopausal women with osteoporosis. It is not recommended for use in children, adolescents, or pregnant women due to potential adverse effects on bone development.
Storage Conditions and Shelf Life:
Store Fosmural granules in a dry place below 25°C. Keep the sachets in the original packaging to protect from moisture. The shelf life of the product is 2 years from the manufacturing date.
Packaging Description:
Fosmural granules are supplied in individual sachets containing 3g of the active ingredient. The sachets are labeled with dosage instructions and expiration date for patient safety.
Scientific Evidence:
Fosmural has been extensively studied in clinical trials for its efficacy in improving bone mineral density and reducing the risk of fractures in postmenopausal women with osteoporosis. Research published in the Journal of Bone and Mineral Research showed a significant increase in lumbar spine bone density after 1 year of treatment with Fosmural.
Additional Information:
It is important to ensure an adequate intake of calcium and vitamin D while using Fosmural granules to support bone health.
