Description

Nimedar (nimesulide) granules 100 mg 2 g. sackets №15

Ingredients

Active ingredient: Each sachet contains 100 mg of nimesulide.

Dosage

Dosage: The recommended dose is one sachet (100 mg) twice daily. Do not exceed this dosage unless directed by a healthcare provider.

Indications

Indications: Nimedar granules are indicated for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders.

Contraindications

Contraindications: Do not use Nimedar granules if you have a history of hypersensitivity to nimesulide or other NSAIDs. Avoid use in patients with active peptic ulcers or gastrointestinal bleeding.

Directions

Directions: Dissolve the contents of one sachet in a glass of water and take orally. It is recommended to take Nimedar with food to reduce the risk of gastrointestinal side effects.

Scientific Evidence

Nimesulide, the active ingredient in Nimedar granules, is a selective COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic properties. Studies have shown that nimesulide effectively reduces pain and inflammation in various inflammatory conditions. Research published in the Journal of Clinical Pharmacology demonstrates the efficacy of nimesulide in managing pain associated with osteoarthritis.

Additional Information

Nimedar granules provide targeted relief for individuals suffering from inflammatory joint conditions. The granule formulation offers quick absorption and rapid onset of action, making it a convenient option for managing acute pain episodes. It is important to follow the prescribed dosage and consult a healthcare professional before initiating treatment with Nimedar.

Pharmacological Effects: Nimesulide exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase-2 (COX-2), thereby reducing the production of pro-inflammatory prostaglandins. This mechanism helps alleviate pain, swelling, and stiffness associated with inflammatory conditions.

Clinical Trials: Clinical trials comparing nimesulide with other NSAIDs have shown similar efficacy in pain relief with a potentially lower risk of gastrointestinal side effects. A study published in the European Journal of Clinical Pharmacology found nimesulide to be well-tolerated and effective in the management of acute musculoskeletal pain.