Description

Nimelgan (nimesulide) granules 100 mg. sachet №30

Ingredients:

Each sachet contains 100 mg of nimesulide.

Dosage:

The recommended dosage for adults is one sachet (100 mg) twice daily.

Indications:

Nimelgan granules are indicated for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders.

Contraindications:

Do not use Nimelgan if you have a history of allergic reactions to nimesulide or other NSAIDs, active peptic ulcer, severe heart failure, or impaired kidney function.

Directions:

Dissolve the contents of one sachet in a glass of water and take it orally. Do not exceed the recommended dosage.

Scientific Evidence:

Nimesulide, the active ingredient in Nimelgan, is a selective COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic properties. Studies have shown that nimesulide effectively reduces pain and inflammation in various inflammatory conditions.

Pharmacological Effects:

When administered, nimesulide inhibits the production of prostaglandins, which are mediators of inflammation and pain. By selectively targeting the COX-2 enzyme, nimesulide reduces inflammation at the site of injury without affecting the protective functions of COX-1 in the stomach lining.

Clinical Trials:

In a comparative study published in the Journal of Clinical Rheumatology, nimesulide was found to be as effective as diclofenac in relieving pain and improving joint function in patients with osteoarthritis. The study also reported a lower incidence of gastrointestinal side effects with nimesulide compared to diclofenac.

Additional Information:

Avoid consuming alcohol while taking Nimelgan as it may increase the risk of gastrointestinal bleeding. If you experience any allergic reactions or severe side effects, discontinue use and consult a healthcare professional immediately.