Description
Nimelgan (Nimesulide) Granules 100 mg
Ingredients:
- Each sachet contains 100 mg of nimesulide.
Dosage:
- The recommended dosage for adults is one sachet (100 mg) twice daily.
Indications:
- Nimelgan granules are indicated for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders.
Contraindications:
- Do not use Nimelgan if you have a history of allergic reactions to nimesulide or other NSAIDs, active peptic ulcer, severe heart failure, or impaired kidney function.
Directions:
- Dissolve the contents of one sachet in a glass of water and take it orally. Do not exceed the recommended dosage.
Scientific Evidence:
Nimesulide, the active ingredient in Nimelgan, is a selective COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic properties. Studies have shown that nimesulide effectively reduces pain and inflammation in various inflammatory conditions.
Pharmacological Effects:
When administered, nimesulide inhibits the production of prostaglandins, which are mediators of inflammation and pain. By selectively targeting the COX-2 enzyme, nimesulide reduces inflammation at the site of injury without affecting the protective functions of COX-1 in the stomach lining.
Clinical Trials:
In a comparative study, nimesulide was found to be as effective as diclofenac in relieving pain and improving joint function in patients with osteoarthritis. Additionally, nimesulide showed a lower incidence of gastrointestinal side effects compared to diclofenac.
Additional Information:
Avoid consuming alcohol while taking Nimelgan as it may increase the risk of gastrointestinal bleeding. If you experience any allergic reactions or severe side effects, discontinue use and consult a healthcare professional immediately.
