Description

Olfen-50 Lactab (diclofenac sodium) tablets 50 mg. №20

Ingredients

Active ingredient: Each tablet contains 50 mg of diclofenac sodium. Other inactive ingredients include lactose, maize starch, povidone, and magnesium stearate.

Dosage

Dosage: The usual dose is one tablet taken two to three times daily with food. Do not exceed the recommended dose unless directed by a healthcare provider.

Indications

Indications: Olfen-50 Lactab is indicated for the relief of pain and inflammation in conditions such as arthritis, ankylosing spondylitis, and acute gout.

Contraindications

Contraindications: Do not use Olfen-50 Lactab if you have a history of allergic reactions to diclofenac or other NSAIDs, or if you have active peptic ulcers or gastrointestinal bleeding.

Directions

Directions: Swallow the tablets whole with a glass of water. It is recommended to take the medication at the same time each day to maintain consistent levels in the body.

Scientific Evidence

Diclofenac, the active ingredient in Olfen-50 Lactab, is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are substances in the body that cause pain and inflammation. Several studies have demonstrated the efficacy of diclofenac in reducing pain and swelling in various inflammatory conditions.

Additional Information

It is important to note that prolonged use of NSAIDs like diclofenac may increase the risk of cardiovascular events and gastrointestinal complications. Patients should be monitored regularly for such adverse effects. Consult a healthcare professional before starting Olfen-50 Lactab, especially if you have a history of heart disease or stomach ulcers.

Pharmacological Effects and Clinical Trials

Diclofenac sodium exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase, thereby reducing the synthesis of prostaglandins involved in the inflammatory process. Clinical trials have shown that diclofenac is effective in managing pain and inflammation associated with various musculoskeletal disorders and inflammatory conditions. One study published in the Journal of Clinical Rheumatology found that diclofenac provided significant pain relief in patients with osteoarthritis of the knee compared to placebo.

Overall, Olfen-50 Lactab (diclofenac sodium) tablets 50 mg. №20 offer a potent anti-inflammatory and analgesic effect, making them a valuable option for individuals suffering from conditions characterized by pain and inflammation.