Description

Piroxicam (Piroxicam) Tablets 10 mg. №10

Ingredients

Active ingredient: Piroxicam 10 mg per tablet.

Dosage

Dosage: The usual dose is 10-20 mg once daily, or as directed by a healthcare professional.

Indications

Indications: Piroxicam is indicated for the relief of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.

Contraindications

Contraindications: Do not use Piroxicam if you have a history of allergic reactions to NSAIDs, active peptic ulcers, or a history of gastrointestinal bleeding.

Directions

Directions: Take Piroxicam tablets with a full glass of water. Do not crush or chew the tablets.

Scientific Evidence

Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins that cause pain and inflammation. Studies have shown that Piroxicam is effective in managing the symptoms of osteoarthritis and rheumatoid arthritis. Research published in the Journal of Clinical Rheumatology demonstrated the efficacy of Piroxicam in reducing pain and improving joint function in patients with osteoarthritis.

Additional Information

Piroxicam should be used at the lowest effective dose for the shortest duration necessary to control symptoms. Long-term use of NSAIDs like Piroxicam may increase the risk of cardiovascular events and gastrointestinal complications. It is important to discuss the risks and benefits of Piroxicam therapy with a healthcare provider.

Pharmacological Effects

Piroxicam exerts its pharmacological effects by inhibiting the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. By blocking the action of cyclooxygenase, Piroxicam reduces inflammation, swelling, and pain in conditions such as arthritis. Additionally, Piroxicam may also possess antipyretic properties, helping to lower fever in certain conditions.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of Piroxicam in managing pain and inflammation in arthritis patients. A comparative study published in the Journal of Rheumatology compared the effectiveness of Piroxicam with other NSAIDs and found it to be equally effective in relieving arthritis symptoms. However, individual responses to different NSAIDs may vary, and the choice of medication should be tailored to each patient’s needs and tolerability.