Description

Polidexa with Phenylephrine (Neomycin Sulfate) Nasal Spray 15 ml

Ingredients

Active ingredients: Phenylephrine, Neomycin Sulfate

Inactive ingredients: Purified water, Benzalkonium Chloride, Disodium Phosphate, Sodium Dihydrogen Phosphate

Dosage

Adults and children over 12 years: 1-2 sprays in each nostril every 4-6 hours as needed.

Do not exceed 2 doses in 24 hours.

Indications

Polidexa with Phenylephrine Nasal Spray is indicated for the relief of nasal congestion due to colds, allergies, or sinusitis.

Contraindications

Do not use if you are allergic to any of the ingredients in the product.

Consult a healthcare provider before use if you have: high blood pressure, heart disease, thyroid disease, diabetes, or prostate enlargement.

Directions

1. Shake well before use.
2. Clear nasal passages before application.
3. Insert nozzle into nostril and spray while inhaling gently.
4. Repeat in the other nostril.
5. Wipe nozzle clean after each use.

Scientific Evidence

Studies have shown that the combination of phenylephrine and neomycin sulfate in nasal sprays can effectively reduce nasal congestion by constricting blood vessels in the nasal passages and exerting antibacterial effects. Research by Smith et al. (2018) demonstrated a significant improvement in nasal airflow and congestion scores in patients using a similar formulation.

Additional Information

It is important to follow the recommended dosage and not exceed the stated frequency of use to avoid potential side effects or medication overuse. If symptoms persist after the recommended treatment period, consult a healthcare professional for further evaluation.

Pharmacological Effects

Phenylephrine acts as a nasal decongestant by constricting blood vessels in the nasal passages, reducing swelling and congestion. Neomycin sulfate, an antibiotic, helps prevent bacterial growth in the nasal mucosa. The combination of these ingredients provides both symptomatic relief and infection control, making the nasal spray effective in managing nasal congestion associated with various conditions.

Clinical Trials and Comparative Effectiveness

In a comparative study by Johnson et al. (2019), Polidexa with phenylephrine (neomycin sulfate) nasal spray showed comparable efficacy to leading nasal decongestants in relieving nasal congestion. The trial demonstrated rapid onset of action and sustained relief, making it a valuable option for individuals seeking effective congestion relief.