Ranselex (celecoxib) capsules 200 mg. №10

Description

Ranselex (celecoxib) capsules 200 mg. №10

Composition

active substance: celecoxib;

1 capsule contains celecoxib 100 mg or 200 mg;

excipients: lactose, monohydrate; povidone; colloidal anhydrous silicon dioxide; sodium lauryl sulfate; croscarmellose sodium; magnesium stearate;

capsule composition: gelatin, sodium lauryl sulfate, titanium dioxide (E171).

Medicinal form

Capsules.

The main physical and chemical properties:

100 mg capsules: white or off-white hard gelatin capsules with the inscription “SS” on the cap and “100” on the capsule body in black ink, which contain white or off-white granular powder;

200 mg capsules: white or off-white hard gelatin capsules, marked “SS” on the cap and “200” on the capsule body in black ink, containing white or off-white granular powder.

Pharmacotherapeutic group

Non-steroidal anti-inflammatory and anti-rheumatic drugs. Coxibs.
ATX code M01A N01.

Pharmacological properties

It is a non-steroidal anti-inflammatory (NSAID), antirheumatic drug. Acts by a specific inhibitory effect on cyclooxygenase-2 (COX-2). This blocks the formation of prostaglandins. Slightly affects the activity of COX-1. The drug has anti-inflammatory, antipyretic and analgesic (pain relieving) effects.

Indications

Ranselex is indicated for degenerative and inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriatic arthritis, etc.).

Contraindications

It is forbidden to use Ranselex:

• with hypersensitivity to the components of this medication;
• with hyperergic reactions in the past associated with the treatment of NSAIDs;
• with bronchial asthma;
• with exacerbation of duodenal / gastric ulcer;
• with severe blood clotting disorders;
• with bleeding from the digestive tract;
• with severe heart failure;
• with gastrointestinal bleeding in the past;
• with severe renal / hepatic impairment;
• after coronary artery bypass grafting;
• with severe violations of the heart (heart failure);
• children.

Application during pregnancy and lactation

Contraindicated.

Method of administration and dosage

Ranselex is used internally (regardless of food), drink plenty of fluids. The standard dosage is 200 mg once or twice a day.
In rheumatoid arthritis, 200-400 mg / day is indicated, divided into 2 doses.

Overdose

In case of an overdose, symptoms such as drowsiness, nausea, and abdominal pain occur. Gastrointestinal bleeding may occur. There is no specific antidote. In case of an overdose in the first four hours, gastric lavage and the use of enterosorbents are indicated. The following shows the maintenance and symptomatic therapy.

Side effects

Side effects that may occur during use include abdominal pain, dizziness, nervousness, blurred vision, shortness of breath, asthma attacks, anemia, various hypersensitivity reactions, arterial hypertension, nausea, tachycardia, malaise, headaches, vomiting, asthenia, hyperkalemia , drowsiness, nightmares, diarrhea, thrombocytopenia (decrease in the number of platelets), constipation, pancytopenia (decrease in the number of all blood cells), fear, purpura, kidney failure, flatulence (bloating), itching, swelling, hypothermia (decrease in temperature), hyperhidrosis (excessive sweating), skin rashes, hot flashes, bronchospasm, jaundice, dyspepsia, erythema, interstitial nephritis, gastritis, dermatitis, stomatitis, angioedema, bleeding from the digestive tract, urticaria, oliguria, ulcer / perforation of the intestine / duodenum / duodenum the appearance of blood in the urine), erythema polyform, facial edema, hepatitis, dysuria, cholestasis, urinary retention (delay urination), Stevens-Johnson syndrome.

If any undesirable reactions occur, the patient should stop taking this medication and contact his doctor.