Revmalgyn (meloxicam) solution for injections ampoules 10 mg/ml. 1.5 ml. №5

Description

Revmalgyn (meloxicam) solution for injections ampoules 10 mg/ml. 1.5 ml. №5 

Composition 

active ingredient: meloxicam;

1 ml of solution contains meloxicam 10 mg;

excipients: meglumine, glycine, poloxamer 188, glycofurol, sodium chloride, sodium hydroxide, water for injection.

Dosage form

Injection.

Basic physical and chemical properties: transparent solution of greenish-yellow color.

Pharmacological group

Nonsteroidal anti-inflammatory and antirheumatic drugs.
ATX code M01A C06.

Pharmacological properties

Revmalgyn is a non-steroidal anti-inflammatory drug (NSAID) of the enolic acid class with anti-inflammatory, analgesic and antipyretic effects.

Meloxicam showed high anti-inflammatory activity in all standard models of inflammation. As with other NSAIDs, its exact mechanism of action remains unknown. However, there is a common mechanism of action for all NSAIDs (including meloxicam): inhibition of the biosynthesis of prostaglandins, which are inflammatory mediators.

Indications

Revmalgyn solution is prescribed for the symptomatic treatment of pain syndrome:

• with arthrosis;
• with ankylosing spondylitis;
• with osteoarthritis;
• with degenerative changes in the joints;
• with rheumatoid arthritis.

Contraindications

Revmalgyn solution is not used:

• with intolerance to the components of the drug (meloxicam, excipients);
• if you are allergic to other NSAIDs;
• when symptoms of bronchial asthma, nasal polyps, angioedema, urticaria appear in the past after taking NSAIDs, acetylsalicylic acid;
• with gastrointestinal, rectal bleeding, perforation associated with NSAID therapy in the past;
• with active or recurrent ulcer or bleeding (two or more confirmed cases) in the past;
• with severe liver failure;
• with severe renal failure (without dialysis);
• with gastrointestinal bleeding, cerebrovascular bleeding in the past;
• in violation of blood clotting;
• with disorders of hemostasis, the simultaneous use of anticoagulants;
• with severe heart failure;
• for the treatment of perioperative pain in coronary artery bypass grafting;
• with an active form of Crohn’s disease, ulcerative colitis;
• children.

Application during pregnancy and lactation

It is forbidden to use Revmalgyn during these periods.

Method of administration and dosage

Revmalgyn solution is administered intramuscularly.
The standard dose is 15 mg / day.
The duration of therapy is set individually.

Overdose

Overdose symptoms: drowsiness, nausea, abdominal pain, lethargy, vomiting, bleeding from the digestive tract, arterial hypertension, acute renal failure, liver dysfunction, coma, cardiac arrest.
Treatment in case of an overdose involves discontinuation of the drug, symptomatic treatment.

Side effects:

• Changes in laboratory parameters: anemia, change in the number of leukocytes, thrombocytopenia, agranulocytosis, increased levels of transaminases, bilirubin, increased levels of creatinine / urea.
• Immune disorders: allergies (including anaphylactic shock).
• Mental disorders: mood changes, confusion, nightmares, disorientation, insomnia.
• Neurological disorders: dizziness, drowsiness, headache.
• Ophthalmic disorders: conjunctivitis, blurred vision.
• Otolaryngological disorders: ringing in the ears.
• Cardiac disorders: palpitations, heart failure.
• Vascular disorders: arterial hypertension, hot flashes.
• Respiratory disorders: asthma attacks, coughs, respiratory tract infections.
• Digestive disorders: abdominal pain, diarrhea, nausea, vomiting, latent or overt gastrointestinal bleeding, esophagitis, gastroduodenal ulcer, stomatitis, belching, constipation, flatulence, perforation, colitis, gastritis, peptic ulcer.
• Hepatobiliary disorders: hepatitis, liver failure, jaundice.
• Skin changes: itching, angioedema, rash, Stevens-Johnson syndrome, urticaria, epidermal necrolysis, bullous dermatitis, photosensitivity, erythema multiforme, exfoliative dermatitis.
• Urinary disorders: hyperkalemia, sodium and water retention, acute renal failure, urinary tract infections, acute urinary retention.
• Musculoskeletal disorders: back pain, arthralgia.
• General disorders: edema, flu-like symptoms.