Revmoxicam (meloxicam) solution for injection ampoules 1% 1.5 ml. №5

Description

Revmoxicam (meloxicam) solution for injection ampoules 1% 1.5 ml. №5

Composition 

active ingredient: meloxicam;

1 ml of the drug contains meloxicam in terms of 100% substance 10 mg;

excipients: meglumine (N-methylglucamine), glycine, poloxamer 188, glycofurol, sodium chloride, 0.1 M sodium hydroxide solution, water for injection.

Dosage form

Injection.

Basic physical and chemical properties: transparent yellow or greenish-yellow liquid.

Pharmacological group

Nonsteroidal anti-inflammatory and antirheumatic drugs.
ATX code M01A C06.

Pharmacological properties

Rheumoxicam is a non-steroidal anti-inflammatory drug (NSAID) of the enolic acid class with anti-inflammatory, analgesic and antipyretic effects.

Meloxicam showed high anti-inflammatory activity in all standard models of inflammation. As with other NSAIDs, its exact mechanism of action remains unknown. However, there is a common mechanism of action for all NSAIDs (including meloxiks): inhibition of the biosynthesis of prostaglandins, which are inflammatory mediators.

Indications  

This drug Revmoxicam solution is used for the treatment of inflammatory and degenerative diseases of the joints, which are accompanied by intense pain syndrome, such as rheumatoid arthritis, acute arthritis, chronic polyarthritis, ankylosing spondylitis.

Also, the drug Revmoxicam solution is used to eliminate pain in osteochondrosis and radiculitis.
It is especially effective in an acute attack of rheumatoid arthritis and ankylosing spondylitis, when oral forms cannot be used.

Contraindications

The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or one of the auxiliary components.

Also contraindicated in patients, patients with a tendency to gastrointestinal bleeding, cerebrovascular bleeding, with severe renal or hepatic insufficiency and severe heart failure.

Application during pregnancy and lactation

This drug is contraindicated in the treatment of pregnant women.
If it is necessary to use the drug, if a woman is lactating, then breastfeeding should be suspended for the duration of treatment.

Method of administration and dosage

It is intended for use in orthopedics, intramuscularly, in the form of injections.

In the treatment of arthrosis in the acute stage, the patient is administered 7.5 mg of the drug 1 time per day. If necessary, it is possible to increase the dose to 15 mg per dose (the maximum possible dose per day).

In the treatment of ankylosing spondylitis and rheumatoid arthritis, 15 mg of the drug is prescribed once a day.

With positive dynamics of the disease, the dose of meloxicam can be reduced to 7.5 mg.

The correction of the duration of treatment, dosages and treatment regimens is determined by the attending physician individually, depending on the individual indicators of the course of the disease.

Children

Revmoxicam solution 15 mg/1.5 ml is contraindicated in children (under 18 years of age).

Overdose

Overdose is accompanied by the development of nausea, vomiting, drowsiness, pain in the epigastric region.
When taking large doses of the drug, the patient may experience an increase in blood pressure, impaired liver and kidney function, respiratory depression, convulsions, collapse, coma and respiratory arrest.
To eliminate the symptoms of an overdose, the patient is treated with symptomatic treatment, and also prescribed the intake of enterosorbents and drinking plenty of fluids.
In the course of studies, it was found that three times intake of cholestyramine significantly increases the rate of elimination of meloxicam.

Side effects

The drug is usually well tolerated. In cases of hypersensitivity, reactions such as:

• nausea, vomiting, diarrhea;
• rash, dermatitis, allergic urticaria.

The use of the drug may also be accompanied by the development of leukopenia, anemia, visual impairment, allergic reactions, headaches, confusion, epigastric pain, esophagitis.
Possible exacerbations of stomach ulcers, stomatitis, gastrointestinal bleeding, kidney malfunction, mucosal edema, liver dysfunction and hepatitis.