Troxevazin (troxerutin) capsules 300 mg. №50

Description

Troxevazin (troxerutin) capsules 300 mg. №50

Composition

active substance: troxerutin;

1 capsule contains troxerutin 300 mg;

Excipients: magnesium stearate, lactose monohydrate; quinoline yellow (E 104), yellow west (E 110), titanium dioxide (E 171), gelatin.

Dosage form

Capsules.

Main physical and chemical properties: hard cylindrical gelatin capsules, № 1, yellow (body – yellow; lid – yellow); capsule content – powder from yellow to yellow-brown color, the presence of conglomerates is allowed, which disintegrate when pressed.

Pharmacotherapeutic group

Angioprotectors. Capillary stabilizing agents. Bioflavonoids. Troxerutin. ATX code C05C A04.

Pharmacological properties

Troxevazin is a mixture of bioflavonoids that contains at least 95% troxerutin; capillarotonizing and venotonizing agent. Has anti-inflammatory and antioxidant effects, inhibits hyaluronidase. Prevents the oxidation of hyaluronic, ascorbic acid and adrenaline, inhibits lipid peroxidation. Troxerutin reduces the increased permeability and fragility of capillaries, prevents damage to the basement membrane of endothelial cells by various factors and, in addition, has antioxidant, membrane-stabilizing, anti-hemorrhagic, anti-inflammatory, venotonizing effect. Reduces edema, improves trophism, improves microcirculation and microvascular perfusion, and reduces other symptoms associated with venous insufficiency or impaired lymphatic outflow.

Indications for the use of Troxevazin capsules :

• with postphlebitic syndrome;
• with chronic venous insufficiency;
• with trophic disorders due to varicose veins, trophic ulcers;
• for hemorrhoids with pain, exudation, itching, bleeding;
• after sclerotherapy of veins, removal of varicose veins (auxiliary treatment);
• with venous insufficiency, hemorrhoids in pregnant women, starting from the second trimester;
• with retinopathy (retinal damage) in patients with diabetes mellitus, atherosclerosis, arterial hypertension.

Contraindications

Troxevazin gel cannot be prescribed for allergies to components, violation of the integrity of the skin at the site of the intended application.
Troxevazin capsules are contraindicated in case of allergy to components, allergy to rutosides, in the first trimester of pregnancy, in case of gastric / duodenal ulcer, chronic gastritis in the acute phase, up to three years of age. Use this medicine with caution (especially for a long time) in case of kidney failure, in children aged 3 to 15 years.

Application during pregnancy and lactation

It is allowed to use this medicine in the form of capsules in the II and III trimesters of pregnancy and during lactation if the expected benefit to the mother outweighs the risk to the fetus / child.
There are no data regarding undesirable effects on the course of pregnancy, fetal development, the condition of the newborn when using the gel.

Method of application and dosage

Troxevazin capsules , taken orally with food. The dosage and duration of the drug is determined by the doctor depending on the nature, severity and course of the disease.

The usual dose is 2 capsules a day. Maintenance treatment – 1 capsule per day for 3-4 weeks. This treatment can be combined with the simultaneous use of Troxevasin, gel. The effectiveness of Troxevasin treatment depends on the regularity of administration, proper dosing and duration of therapy. Clinical experience shows that sometimes the desired effect is observed at doses exceeding 600 mg (2 capsules) per day.

Children

Experience with the drug for the treatment of children (under 18 years) is limited, so the use of this drug is not recommended.

Overdose

In case of an overdose of capsules, the following signs of poisoning may appear: agitation, urge to vomit, headache, a feeling of blood rush to the face.
Overdose treatment: it is necessary to flush the stomach (if lavage is impossible, vomiting should be artificially induced), take any enterosorbent (for example, activated carbon), if necessary, carry out symptomatic treatment.
Due to the external method of using the gel, there is no danger of an overdose. In case of accidental use of a large amount of gel inside, it is necessary to carry out general measures for removing the drug from the body: gastric lavage, the use of saline laxatives, if necessary, symptomatic and supportive treatment. Peritoneal dialysis should be performed if indicated.

Side effects

When treating with gel, allergic skin reactions can be observed in the form of urticaria (urticaria), eczema, dermatitis.
When treating with capsules, nausea, heartburn, diarrhea (frequent and loose stools), headache, erosive and ulcerative lesions of the gastrointestinal mucosa, “hot flushes” of blood to the face are possible. There is a low probability of developing an allergic reaction, manifested by itching, redness of the skin, urticaria, skin irritation, shortness of breath. More severe allergic manifestations are not excluded: Quincke’s edema (rapidly developing edema of the eyes, face or part of it, lips, larynx – with impaired airway patency), anaphylactic shock (manifested by severe itching of the skin, quickly spreading over the skin, a sharp drop in blood pressure, vomiting , loose stools, laryngeal edema, disturbance of the vital organs, noisy and labored breathing, pallor or cyanosis of the skin, a sharp narrowing of the bronchi, larynx, leading to acute difficulty in breathing, loss of consciousness).