Description
Dicloberl-50 (Diclofenac Sodium) Suppositories 50 mg. №10
Composition
Active Ingredient: Diclofenac sodium 50 mg.
Dicloberl-50 suppositories also contain other inactive ingredients.
Mechanism of Action
Dicloberl-50 suppositories exert their pharmacological effects by inhibiting the enzyme cyclooxygenase, thereby reducing the synthesis of prostaglandins involved in the inflammatory process.
Pharmacological Properties
The pharmacological properties of Dicloberl-50 suppositories include analgesic, anti-inflammatory, and antipyretic actions, making them effective in managing pain and inflammation associated with various musculoskeletal disorders.
Indications for Use
Dicloberl-50 suppositories are indicated for the relief of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout.
Contraindications
Do not use Dicloberl-50 suppositories if you:
- Have a history of allergic reactions to diclofenac or other NSAIDs.
- Are in the third trimester of pregnancy.
- Have active peptic ulcers or gastrointestinal bleeding.
Side Effects
Common side effects of Dicloberl-50 suppositories may include gastrointestinal disturbances, such as nausea and abdominal pain, as well as skin reactions like itching or rash. In rare cases, severe allergic reactions or liver toxicity may occur.
Usage Instructions
Adults: The usual dosage is one suppository inserted into the rectum once or twice daily. It is recommended to consult a healthcare professional for personalized dosing instructions.
Benefits Compared to Analogues
Dicloberl-50 suppositories offer the advantage of targeted delivery and localized action, resulting in potentially lower systemic side effects compared to oral formulations of diclofenac.
Suitable Patient Groups
Dicloberl-50 suppositories can be used in adult patients, including the elderly, for the management of pain and inflammation in musculoskeletal disorders. They are not recommended for use in children.
Storage and Shelf Life
Store Dicloberl-50 suppositories in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the product after the specified shelf life has passed.
Packaging Description
Dicloberl-50 suppositories are typically packaged in blister packs containing 10 suppositories per pack. Each suppository is individually wrapped for hygienic and convenient use.
Clinical Evidence and Proven Effectiveness
Dicloberl-50 (Diclofenac Sodium) suppositories have demonstrated efficacy in managing pain and inflammation associated with musculoskeletal conditions. Clinical studies have shown the superior pain relief provided by diclofenac suppositories compared to placebo, particularly in patients with osteoarthritis (Journal of Clinical Rheumatology).
