Description

Fort-gel Composition

active substance: 1 g of gel contains 0.025 g of ketoprofen
excipients: ethanol 96%, carbomer, triethanolamine, lavender oil, purified water.

Fort-gel Dosage form

Gel 2.5%.

Basic physical and chemical properties:

gel is colorless, almost transparent, of uniform consistency, with a fragrant odor.

Pharmacological group

Topical non-steroidal anti-inflammatory drugs. Ketoprofen. ATX code М02А А10.

Fort-gel Pharmacological properties

Pharmacological.

Ketoprofen belongs to the NSAID derivatives of propionic acid. It has analgesic and anti-inflammatory effects due to inhibition of the action of cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), inhibition of bradykinin activity, stabilization of lysosomal membranes and inhibition of macrophage migration. Ketoprofen has analgesic and anti-inflammatory effects at an early stage (vascular phase) and at a late stage (cellular phase) of the inflammatory response. Ketoprofen also inhibits platelet aggregation.

Pharmacokinetics.

When applied topically, ketoprofen gel is absorbed from the skin and penetrates locally into inflammatory tissues. Absorption to systemic circulation is very low (only 5% of the dose is applied).

The preparation applied to the skin quickly penetrates into the problem area and maintains the therapeutic concentration in it. Absorption into the general bloodstream, on the contrary, is slow. When applied to the skin of a gel containing 50 to 150 mg of ketoprofen, after 5-8 hours in the blood plasma, the concentration of the active substance does not exceed 0.08-0.15 μg / ml, practically does not have a clinically significant effect on the body.

Indications

Post-traumatic pain in muscles and joints, tendovaginitis.

Contraindications

Hypersensitivity to ketoprofen or other excipients of the drug, salicylates and other non-steroidal anti-inflammatory drugs.

Hypersensitivity reactions are known, for example, symptoms of bronchial asthma, allergic rhinitis or urticaria after the use of ketoprofen, other NSAIDs, acetylsalicylic acid, fenofibrate, tiaprofenic acid. Exacerbation of gastric ulcer or duodenal ulcer. History of gastrointestinal bleeding. Chronic dyspepsia (discomfort and pain in the upper abdomen). Severe renal failure. Skin injuries and diseases, skin trauma, irritation, itching, acne, burns (rash, eczema, skin infections). The gel should not be applied to damaged skin (dermatoses, open and infected wounds). Do not use sealed dressings.

Any history of photosensitivity. A history of skin manifestations of allergies arising from the use of ketoprofen, other excipients of the drug, fenofibrate, tiaprofenic acid, blockers of ultraviolet (UV) rays or perfumes. Influence of sunlight (even on a foggy day), including indirect sunlight and UV radiation in a tanning bed during the entire treatment period and for another 2 weeks after stopping treatment.

Pregnancy (III trimesters), lactation period. Age up to 15 years.