Description

Acnetin (Isotretinoin) Capsules 8 mg. №30

Ingredients:

Each capsule contains 8 mg of isotretinoin.

Dosage:

The recommended dosage is determined by the prescribing healthcare provider. It is typically taken once or twice daily with food.

Indications:

Acnetin capsules are indicated for the treatment of severe recalcitrant nodular acne. It is used when other treatments have not been effective.

Contraindications:

Do not use Acnetin if pregnant or breastfeeding. It is contraindicated in patients with a history of hypersensitivity to isotretinoin.

Directions:

Take Acnetin exactly as prescribed by your healthcare provider. Follow all instructions on the prescription label.

Scientific Evidence:

Isotretinoin, the active ingredient in Acnetin capsules, is a retinoid that works by affecting the sebaceous glands in the skin. It reduces the production of sebum, which can lead to acne. Studies have shown that isotretinoin is highly effective in treating severe nodular acne, with significant improvements seen in a majority of patients within a few months of treatment.

Additional Information:

It is important to follow up with your healthcare provider regularly while taking Acnetin to monitor for any potential side effects. Common side effects may include dry skin, chapped lips, and temporary worsening of acne. In rare cases, isotretinoin can cause more serious side effects, so it is crucial to report any unusual symptoms to your doctor.

Pharmacological Effects:

Isotretinoin works by targeting the abnormal skin cell growth that leads to acne. It reduces inflammation and prevents the formation of comedones. Additionally, isotretinoin has been shown to have anti-inflammatory effects, which contribute to its efficacy in treating severe acne.

Clinical Trials and Comparative Effectiveness:

Clinical trials have demonstrated the superior efficacy of isotretinoin compared to other acne treatments, especially in cases of severe nodular acne that has not responded to conventional therapies. Isotretinoin has been shown to provide long-lasting remission of acne symptoms in many patients, making it a valuable option for those with treatment-resistant acne.

References:
1. Layton AM. “The use of isotretinoin in acne.” Dermatoendocrinol. 2009;1(3):162-169.
2. Rademaker M. “Isotretinoin: dose, duration and relapse. What does 30 years of usage tell us?” Australas J Dermatol. 2013 Nov;54(4):157-62.