AlergoDerm (fluocinolon) ointment 0.25 mg/g. 15 g. tube

active ingredient: fluocinolone;

1 g of the drug contains fluocinolone acetonide 0.25 mg;

excipients : propylene glycol, citric acid, lanolin, white soft paraffin.

Corticosteroids for use in dermatology. ATX code D07A C04.

Fluocinolone acetonide is an effective synthetic corticosteroid for external use. When applied as an ointment at a concentration of 0.25 mg / g, it has a strong anti-inflammatory, anti-allergic, anti-allergic and vasoconstrictive effect. It has lipophilic properties and is easily absorbed through the skin. Already after applying 2 g of the ointment, ACTH production by the pituitary gland may decrease as a result of inhibition of the adrenal gland – pituitary gland.

Fluocinolone acetonide easily penetrates into the stratum corneum of the skin, where it gradually accumulates and is determined even 15 days after application. Not metabolized in the skin. After absorption, it is systemically biotransformed mainly in the liver. It is excreted in the urine and in smaller quantities – with bile, mainly in the form of a compound with glucuronic acid, and also in a small amount – unchanged.

The absorption of fluocinolone acetonide through the skin is enhanced when applied to sensitive skin of anatomical folds of the body and face, as well as to skin with damaged epidermis or an inflammatory process. The use of an occlusive dressing causes an increase in skin temperature and moisture, which also leads to an increase in the absorption of fluocinolone acetonide. In addition, absorption is enhanced with frequent use of the drug and on large areas of the skin. Absorption through the skin is higher in adolescents than in adult patients.

Short-term treatment of acute and severe non-infectious inflammatory skin diseases (without exudation), accompanied by persistent itching or hyperkeratosis: seborrheic dermatitis, atopic dermatitis, nodular urticaria (papular urticaria), allergic contact dermatitis, erythema multiforme, lupus erythematosus, psoriasis, lichen planus.

Skin manifestations of syphilis, skin tuberculosis, pyoderma, chickenpox, herpes, actinomycosis, blastomycosis, sporotrichosis, diaper dermatitis, anogenital itching, nevus; atheroma, hemangioma, xanthoma, skin neoplasms, wounds and ulcerative lesions of the skin, wounds at the application sites, numerous psoriatic plaques, trophic ulcers associated with varicose veins, erosive and ulcerative lesions of the digestive tract.

Do not use the ointment for bacterial, viral and fungal skin infections, acne vulgaris and rosacea, perioral dermatitis (dermatitis perioralis), after preventive vaccinations, as well as in case of confirmed hypersensitivity to fluocinolone acetonide or other corticosteroids and other components of the drug.

Treatment must be carried out under the supervision of a physician.

Before each re-application of the drug, the remnants of the pre-application ointment should be washed off with soapy water or an antiseptic solution. It is recommended to wear loose clothing during treatment. Do not apply to the skin of the mammary glands.

Do not use the cream at the same time as other topical medicines.

Periodic monitoring of adrenal function is shown by determining cortisol in the blood and urine after stimulation of the adrenal glands with ACTH with prolonged use.

Under special control, the ointment should be used in patients with psoriasis, since topical application of glucocorticoids to areas affected by psoriasis can lead to the spread of the pathological process or relapse caused by the development of tolerance, as well as the risk of generalized pustular psoriasis and systemic toxicity caused by skin dysfunction.

Do not use the drug for more than 2 weeks without a break. With prolonged use on large areas of the skin, the incidence of side effects and the possibility of developing edema, arterial hypertension, hyperglycemia, and a decrease in body resistance increase.

With external use of the drug, the following are possible: a decrease in the production of ACTH by the pituitary gland through suppression of the adrenal glands – pituitary gland, a decrease in the level of cortisol in the blood and the development of iatrogenic Cushing’s syndrome, disappears after the drug is discontinued.

If an infection develops at the site of application of the ointment, appropriate antibacterial or antifungal treatment should be carried out. If the symptoms of the infection do not disappear, it is necessary to stop using the drug for the period of treatment of the infection.

Avoid applying the drug to the eyelids or the skin around the eyes in patients with closed-angle and open-angle glaucoma, as well as in patients with cataracts due to a possible increase in the symptoms of the disease. Avoid getting the drug in the eyes. If the skin is irritated at the site of application of the ointment, it should be canceled.

On the skin of the face, as well as on the axillary region, apply only in case of special need, since there may be an increase in absorption and a high risk of side effects (telangiectasia, dermatitis perioralis), even after a short application.

The drug should be used with caution in the presence of subcutaneous tissue atrophy, mainly in the elderly.

Since the preparation contains propylene glycol, it may cause skin irritation upon application.

Since the drug contains lanolin, its use may cause local reactions (eg contact dermatitis).

The drug is intended for topical use. Apply a thin layer of ointment on the affected skin 1-2 times a day.

Do not apply ointment under an occlusive dressing. Only in the case of psoriasis can a closed bandage be used, which should be changed every day.

Treatment should not be continued continuously for more than 2 weeks. Do not use on the face for more than 1 week. During the week, it is recommended to use no more than 15 g of ointment (1 tube).

It should be used with caution under the supervision of a physician, the drug to children aged 2 years; such application is possible only 1 time per day and on a small area of ​​the skin; Do not apply on face.