Alfarecin (Interferon alfa-2 human recombinant) rectal suppositories 3 mln IU №10

active ingredient: Interferon alfa-2 human recombinant;

1 suppository contains Interferon alfa-2 human recombinant 3 million IU;

excipients: dextran; trilon B; emulsifier T2; citric acid monohydrate, sodium hydroxide polysorbate; solid fat.

Immunostimulants. Interferon alfa-2b. ATX code L03A B05.

Alfarekin is a dosage form of Interferon alfa-2 human recombinant, synthesized by E. coli cells based on a gene encoding a product identical to human interferon alpha-2b, using phage-dependent genetic engineering biotechnology.

Alfarekin, like natural leukocyte interferon, has a wide range of biological activity.

Pharmacological.

Of paramount importance is a pronounced antiviral and immunostimulating effect, as well as the activation of antitumor protection. Interferons (IFN) regulate the relationship between the links of cellular and humoral immunity. Under the influence of IFN, the differentiation and activity of natural killer cells and T-lymphocytes increases, which determines the active course of cellular immunity reactions. IFNs regulate the production of inflammatory mediators, influence the migration of inflammatory cells to the pathological focus, stimulate phagocytosis and other bactericidal reactions, normalizing the dynamics of the inflammatory process. The influence of interferons on the expression of molecules of the major histocompatibility complex and the cytokine spectrum determines the antiallergic effect.

IFNs directly affect the main stages of replication of intracellular pathogens, stop their reproduction, and provide effective lysis of infectious agents. IFNs are characterized by high antiviral and antichlamydial activity.

The use of Interferon alfa-2 human recombinant as part of the complex treatment of chronic infectious and inflammatory diseases can increase the effectiveness of antibacterial and other drugs used for treatment, as well as reduce their systemic toxic effects, and shorten the duration of treatment.

Alfarekin in suppositories is used for children and adults as monotherapy and as part of complex treatment for various viral and viral-bacterial infections. The drug is indicated for use in infectious and inflammatory diseases of the respiratory and urogenital tracts, cervical dysplasia, meningitis, sepsis, childhood viral infectious diseases (measles, rubella, chicken pox, mumps), in order to rehabilitate children who often suffer from respiratory infections.

Hypersensitivity to interferon alfa-2b or other components of the drug; the patient has thyroid dysfunction; the presence of severe visceral disorders in patients with Kaposi’s sarcoma; severe cardiovascular disease; psoriasis, severe violations of the liver and / or kidneys; epilepsy and other diseases of the central nervous system (including functional ones); chronic hepatitis on the background of progressive or decompensated liver cirrhosis; chronic hepatitis in patients receiving or recently received immunosuppressant therapy (other than a short course of corticosteroids); autoimmune hepatitis or other autoimmune diseases in history. Inhibition of the myeloid germ of hematopoiesis.