Aminosteril solution for infusions 500 ml. vial №10

1000 ml solution contains

active substances:

L-isoleucine 10.4 g;

L-leucine 13.09 g;

L-lysine monoacetate 9.71 g;

(L-lysine) 6.88 g;

L-methionine 1.1 g;

N-acetyl-L-cysteine ​​0.7 g;

(L-cysteine) 0.52 g;

L-phenylalanine 0.88 g;

L-threonine 4.4 g;

L-tryptophan 0.7 g;

L-valine 10.08 g;

L-arginine 10.72 g;

L-histidine 2.8 g;

aminoacetic acid 5.82 g;

L-alanine 4.64 g;

L-proline 5.73 g;

L-serine 2.24 g;

glacial acetic acid 4.42 g;

excipients : water for injection.

The total content of amino acids – 80 g / l.

The total nitrogen content is 12.9 g/l.

Solution for infusion.

Basic physical and chemical properties: transparent solution.

pH = 5.7 – 6.3. NaOH titer – 12 – 25 mmol / l. Theoretical osmolarity – 770 mosm / l.

Solutions for parenteral nutrition.

ATX code B05B A01.

Signs of liver failure in patients are:

• an increase in the concentration of ammonium in the blood plasma
• severe imbalance of amino acids in the blood, as a result of which the concentrations of branched-chain amino acids (valine, leucine, isoleucine) decrease, and the concentrations of aromatic amino acids (tyrosine, phenylalanine, tryptophan) and methionine increase;
• hypercatabolism.

The combination of these factors leads to cerebral changes, mainly causing the development of hepatic encephalopathy and hepatic coma.

Within the framework of infusion therapy, the normalization of these factors is facilitated by the introduction of amino acid solutions that contain a high proportion of branched acids and at the same time a low proportion of aromatic acids and methionine.

Amino acids are an integral part of the proteins of ordinary food and are used for the synthesis of tissue proteins, and any excess is sent to a number of metabolic processes.

Studies have shown a thermogenic effect of amino acid infusions.

Aminosteril when administered intravenously, as part of parenteral nutrition, has 100% bioavailability.

The composition of the drug takes into account amino acid metabolism disorders in severe liver failure. The content of methionine, phenylalanine and tryptophan is reduced, but it is sufficient to meet the requirements, and the content of branched chain amino acids (leucine, isoleucine and valine) is significantly increased (42%) compared with solutions intended for use in patients with normal liver function.

For parenteral administration of amino acids in severe forms of liver failure with / without hepatic encephalopathy, when oral or enteral nutrition is not possible or insufficient, or contraindicated.

Violation of amino acid metabolism, metabolic acidosis, hypervolemia, hyponatremia, hypokalemia, renal failure, decompensated heart failure, shock, hypoxia, hypersensitivity to the components of the drug.