Description

Amitriptyline (amityptilline) Hydrochloride Tablets 25 mg. №25

Ingredients:

Each tablet contains 25 mg of Amitriptyline hydrochloride.

Dosage:

The usual adult dose is 25-150 mg per day in divided doses. Dosage should be adjusted according to individual response and tolerance.

Indications:

Amitriptyline tablets are indicated for the treatment of depression. It may also be used for the relief of symptoms of anxiety disorders.

Contraindications:

Do not use Amitriptyline if you have a history of hypersensitivity to tricyclic antidepressants. It is contraindicated in acute recovery phase following a myocardial infarction.

Directions:

Take this medication by mouth, usually 1-4 times daily or as directed by your doctor. It may be taken with food to reduce stomach upset.

Scientific Evidence:

Amitriptyline is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain such as serotonin and norepinephrine. These neurotransmitters play a key role in regulating mood and emotions. Several studies have demonstrated the efficacy of Amitriptyline in the treatment of depression and anxiety disorders. For example, a study published in the Journal of Clinical Psychiatry showed that Amitriptyline was effective in reducing symptoms of major depressive disorder.

Additional Information:

It is important to follow the prescribed dosage and not to suddenly stop taking Amitriptyline as it may lead to withdrawal symptoms. Regular monitoring by a healthcare provider is necessary during treatment with this medication. Inform your doctor about any other medications or supplements you are taking to avoid potential drug interactions.

Pharmacological Effects: Amitriptyline exerts its antidepressant effects by inhibiting the reuptake of serotonin and norepinephrine, leading to increased levels of these neurotransmitters in the brain. This action helps in improving mood and reducing symptoms of depression.

Clinical Trials: Clinical trials have shown that Amitriptyline is as effective as other antidepressants in the treatment of depression. A study published in JAMA Psychiatry compared the efficacy of different antidepressants and found that tricyclic antidepressants, including Amitriptyline, were equally effective in managing depressive symptoms.