Description

Ampisulbin (Ampicillin, Sulbactam) 1.5 g Vial

Ingredients

Ampicillin and Sulbactam are the active ingredients in Ampisulbin. Ampicillin is a penicillin-type antibiotic, while Sulbactam is a beta-lactamase inhibitor that helps extend the spectrum of Ampicillin.

Dosage

The usual dosage of Ampisulbin is 1.5 grams (1 vial) every 6 hours. Dosage may vary based on the severity of the infection and the patient’s condition. It is important to follow the healthcare provider’s instructions.

Indications

Ampisulbin is indicated for the treatment of various bacterial infections, including respiratory tract infections, skin and soft tissue infections, intra-abdominal infections, and urinary tract infections caused by susceptible bacteria.

Contraindications

Do not use Ampisulbin if you are allergic to penicillins or beta-lactamase inhibitors. It is important to inform your healthcare provider about any allergies or medical conditions before starting treatment.

Directions

Ampisulbin is administered intravenously by a healthcare professional. It is important to complete the full course of treatment as prescribed, even if symptoms improve before the treatment is finished.

Scientific Evidence

Studies have shown the efficacy of Ampisulbin in treating a wide range of bacterial infections. Research published in the Journal of Antimicrobial Chemotherapy demonstrated the effectiveness of Ampicillin-Sulbactam combinations in combating multidrug-resistant bacteria.

Additional Information

Ampisulbin’s combination of Ampicillin and Sulbactam provides a synergistic effect, where Sulbactam protects Ampicillin from being degraded by beta-lactamases, thus enhancing its antibacterial activity. Clinical trials have shown Ampisulbin to be well-tolerated with a low incidence of side effects.

Pharmacological Effects: Ampicillin inhibits bacterial cell wall synthesis, leading to cell death. Sulbactam enhances Ampicillin’s activity by inhibiting beta-lactamase enzymes produced by resistant bacteria.

Comparative Effectiveness: Ampisulbin has shown comparable efficacy to other combination antibiotics like amoxicillin-clavulanate in treating various infections. However, its broader spectrum of activity against beta-lactamase-producing bacteria sets it apart.