Angio-Betargyn (arginine hydrochloride) solution for infusions 42 mg/ml. 100 ml. vial №1

active ingredient: arginine hydrochloride;

1 bottle (100 ml) contains arginine hydrochloride 4.2 g;

excipients: water for injection.

Ionic composition per 1000 ml of the drug: С6Н14N4O2 – 200 mmol; Cl- – 200 mmol.

Solution for infusion.

Basic physical and chemical properties : clear, colorless or slightly yellowish-brown liquid.

Blood substitutes and perfusion solutions. Additional solutions for intravenous administration. Amino acids. Arginine hydrochloride. ATX code B05X B01.

Arginine (a-amino-d-guanidinovaleric acid) is an amino acid that belongs to the class of conditionally essential amino acids and is an active and versatile cellular regulator of numerous vital functions of the body, exhibiting protective effects that are important in a critical state of the body.

Arginine hydrochloride has antihypoxic, membrane stabilizing, cytoprotective, antioxidant, antiradical, detoxifying activity, acts as an active regulator of intermediate metabolism and energy supply processes, plays a certain role in maintaining hormonal balance in the body. It is known that arginine increases the blood levels of insulin, glucagon, growth hormone and prolactin, takes part in the synthesis of proline, polyamine, agmatine, is involved in the processes of fibrinogenolysis, spermatogenesis, and has a membrane-depolarizing effect.

Arginine is one of the main substrates in the urea synthesis cycle in the liver. The hypoammoniemic effect of the drug is realized by activating the conversion of ammonia into urea. It has a hepatoprotective effect due to antioxidant, antihypoxic and membrane stabilizing activities, positively affects the processes of energy supply in hepatocytes.

Arginine hydrochloride is a substrate for NO-synthase, an enzyme that catalyzes the synthesis of nitric oxide in endotheliocytes. The drug activates guanylate cyclase and increases the level of cyclic guanidine monophosphate (cGMP) in the vascular endothelium, reduces the activation and adhesion of leukocytes and platelets to the vascular endothelium, inhibits the synthesis of adhesion proteins VCAM-1 and MCP-1, thereby preventing the formation and development of atherosclerotic plaques, inhibits the synthesis of endothelin 1, which is a powerful vasoconstrictor and stimulator of proliferation and migration of smooth myocytes of the vascular wall. Arginine hydrochloride also inhibits the synthesis of asymmetric dimethylarginine, a powerful endogenous stimulator of oxidative stress. The drug stimulates the activity of the thymus gland, which produces T-cells, regulates blood glucose levels during exercise. It has an acid-producing effect and contributes to the correction of acid-base balance.

With continuous infusion, the maximum concentration of arginine hydrochloride in blood plasma is reached 20-30 minutes after the start of administration. Arginine crosses the placental barrier, is filtered in the renal glomeruli, but is almost completely reabsorbed in the renal tubules.

Metabolic alkalosis, hyperammonemia, atherosclerosis of the vessels of the heart and brain, atherosclerosis of peripheral vessels, including those with manifestations of intermittent claudication, diabetic angiopathy, arterial hypertension, chronic heart failure, hypercholesterolemia, chronic obstructive pulmonary disease, pulmonary hypertension, fetal growth retardation and preeclampsia – as part of complex therapy.