Description

Arifam (indapamide) tablets with modified release 1.5 mg/5 mg. №30

Ingredients

Active ingredient: Indapamide. Other ingredients may include lactose, maize starch, hypromellose, and magnesium stearate.

Dosage

Recommended dosage: The usual dose is one tablet daily, preferably in the morning. The dosage may vary depending on the individual’s condition and response to treatment.

Indications

Arifam tablets are indicated for the treatment of hypertension (high blood pressure) and edema (fluid retention) associated with conditions such as congestive heart failure.

Contraindications

Do not use Arifam tablets if you are allergic to indapamide or any other ingredients in the formulation. It is contraindicated in patients with severe renal impairment, hepatic encephalopathy, and hypokalemia.

Directions

Take Arifam tablets exactly as prescribed by your healthcare provider. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Indapamide, the active ingredient in Arifam tablets, is a thiazide-like diuretic with proven efficacy in the management of hypertension. Studies have shown that indapamide effectively reduces blood pressure and helps in the management of edema associated with heart failure. Research published in the Journal of Hypertension has demonstrated the long-term benefits of using indapamide in reducing cardiovascular events.

Additional Information

It is important to monitor electrolyte levels, especially potassium, while taking Arifam tablets. Regular blood pressure checks and kidney function tests are recommended during treatment. Inform your healthcare provider about any other medications or supplements you are taking to avoid potential drug interactions.

Pharmacological Effects: Indapamide works by promoting diuresis (increased urine production) and vasodilation (widening of blood vessels), leading to a reduction in blood pressure. It acts on the kidneys to increase the excretion of sodium and water, thus reducing the volume of circulating blood and lowering blood pressure.

Clinical Trials: Clinical trials have demonstrated the efficacy of indapamide in reducing cardiovascular events, including stroke and heart attacks, in patients with hypertension. A study published in the British Medical Journal showed a significant reduction in the incidence of stroke with the use of low-dose indapamide compared to a placebo.