Description

Azaleptol (Clozapine) Tablets

Composition

Active ingredient: Clozapine

Other ingredients: lactose monohydrate, maize starch, povidone, magnesium stearate.

Mechanism of Action

Clozapine acts as an antagonist at various neurotransmitter receptors in the brain, including dopamine and serotonin receptors, contributing to its efficacy in treating schizophrenia.

Pharmacological Properties

Azaleptol (Clozapine) tablets are indicated for the treatment of severe schizophrenia in patients who have not responded to standard antipsychotic medications.

Indications for Use

Azaleptol (Clozapine) is indicated for the treatment of severe schizophrenia in patients who have not responded to standard antipsychotic medications.

Contraindications

Azaleptol (Clozapine) should not be used in patients with a history of agranulocytosis, severe neutropenia, or hypersensitivity to clozapine.

Side Effects

Common side effects of Azaleptol (Clozapine) may include drowsiness, dizziness, constipation, and increased salivation. Serious side effects such as agranulocytosis and myocarditis may occur.

Usage Instructions

The usual starting dose of Azaleptol (Clozapine) is 12.5 mg once or twice daily, with gradual increments to a maintenance dose ranging from 300 mg to 450 mg per day in divided doses. It should be taken orally with or without food as directed by a healthcare provider.

Benefits Compared to Analogues

Azaleptol (Clozapine) has shown superior efficacy in the treatment of refractory schizophrenia compared to other antipsychotic medications. It helps in reducing positive and negative symptoms of schizophrenia and improving overall quality of life in patients.

Suitable Patient Groups

Azaleptol (Clozapine) is suitable for adult patients with severe schizophrenia who have not responded to standard antipsychotic medications. It may be prescribed cautiously in children and the elderly under close medical supervision.

Storage and Shelf Life

Azaleptol (Clozapine) tablets should be stored at room temperature away from moisture and heat. The shelf life is typically indicated on the packaging and should be checked before use.

Packaging Description

Azaleptol (Clozapine) tablets are typically available in blister packs of 50 tablets each. The packaging should be intact and undamaged before use.

Clinical Evidence and Proven Effectiveness

Azaleptol (Clozapine) has demonstrated its effectiveness in reducing symptoms and improving outcomes in patients with treatment-resistant schizophrenia. Clinical trials have shown its superiority over other antipsychotic drugs in managing this challenging condition.