Description

Cisplatina Accord (cisplatin) concentrate for infusions 1 mg/ml. 100 ml. №1 vial

Ingredients

Active ingredient: Cisplatin
Other ingredients: Sodium chloride, hydrochloric acid, and water for injections.

Dosage

Dosage: The dosage of Cisplatina Accord should be calculated based on the patient’s body surface area and renal function. It is administered intravenously over a specific period as directed by a healthcare professional.

Indications

Indications: Cisplatina Accord is indicated for the treatment of various types of cancers, including testicular, ovarian, bladder, and lung cancers. It works by interfering with the growth of cancer cells.

Contraindications

Contraindications: Cisplatina Accord is contraindicated in patients with severe renal impairment, hearing loss, and hypersensitivity to platinum-containing compounds.

Directions

Administration: Cisplatina Accord should only be administered by healthcare professionals experienced in the use of cytotoxic agents. It is given as an intravenous infusion after proper dilution.

Scientific Evidence

Cisplatin, the active ingredient in Cisplatina Accord, has been extensively studied for its efficacy in various cancers. Research published in the “Journal of Clinical Oncology” has shown that cisplatin-based regimens are effective in the treatment of advanced bladder cancer (Source: https://ascopubs.org/doi/abs/10.1200/JCO.2009.23.5464).

Additional Information

Cisplatina Accord is a potent chemotherapy drug that works by binding to DNA and disrupting cell division, ultimately leading to cell death. Clinical trials have demonstrated its effectiveness in combination therapies for different types of cancers, improving overall survival rates and quality of life for patients.

Pharmacological Effects: Cisplatin exerts its antitumor effects by forming cross-links with DNA, which inhibits DNA replication and transcription, leading to cell death. It also triggers apoptosis in cancer cells, preventing their proliferation.

Comparative Effectiveness: Cisplatin is considered one of the most effective chemotherapy drugs, especially in combination regimens. Studies have shown its superiority in certain cancers compared to other platinum-based drugs, highlighting its importance in cancer treatment protocols.