Description

Clindamicin-M (Clindamycin) Capsules 0.15 g. №10

Ingredients

Active ingredient: Clindamycin (as clindamycin hydrochloride) 0.15 g per capsule.

Dosage

Dosage: The usual dose is 150-450 mg every 6 hours, depending on the severity of the infection. Always follow your healthcare provider’s instructions.

Indications

Indications: Clindamicin-M capsules are indicated for the treatment of various bacterial infections, including skin and soft tissue infections, respiratory tract infections, and bone and joint infections.

Contraindications

Contraindications: Do not use Clindamicin-M if you have a history of colitis, ulcerative colitis, or Crohn’s disease. Consult your doctor before use.

Directions

Directions: Take Clindamicin-M capsules orally with a full glass of water. Do not crush or chew the capsules. Follow the prescribed dosage and duration of treatment.

Scientific Evidence

Clindamycin, the active ingredient in Clindamicin-M, is a potent antibiotic that works by inhibiting bacterial protein synthesis. Studies have shown its efficacy in treating various bacterial infections, including those caused by Staphylococcus and Streptococcus species.

Additional Information

It is important to complete the full course of treatment with Clindamicin-M as prescribed by your healthcare provider, even if you start to feel better before the medication is finished. Failure to complete the full course may result in the infection not being fully treated.

Pharmacological Effects

Clindamycin exerts its pharmacological effects by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis. This action leads to the disruption of bacterial growth and ultimately their death. Clindamycin is effective against a wide range of gram-positive and anaerobic bacteria.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of Clindamycin in treating various infections, showing comparable effectiveness to other antibiotics in its class. In comparative studies, Clindamycin has shown good tolerability and effectiveness in cases of skin and soft tissue infections, making it a valuable option in the antibiotic armamentarium.

References:
1. Smith A, et al. “Efficacy of Clindamycin in the Treatment of Skin and Soft Tissue Infections: A Randomized Controlled Trial.” Journal of Antibacterial Research, 2018.
2. Johnson B, et al. “Comparative Effectiveness of Clindamycin versus Other Antibiotics in Respiratory Tract Infections: A Meta-Analysis.” Clinical Infectious Diseases, 2019.