Description
Clofranil (Clomipramine) Coated Tablets 25 mg. №50
Ingredients:
Each coated tablet contains 25 mg of Clomipramine hydrochloride.
Mechanism of Action:
Clomipramine, the active ingredient in Clofranil, is a tricyclic antidepressant that functions by inhibiting the reuptake of serotonin in the brain. This action leads to increased levels of serotonin, a neurotransmitter crucial for mood and emotional regulation. By enhancing serotonin levels, Clomipramine aids in alleviating symptoms associated with obsessive-compulsive disorder (OCD) and major depressive disorder.
Pharmacological Properties:
Clomipramine exerts its therapeutic effects through its ability to modulate serotonin levels in the brain, thereby influencing mood, behavior, and emotional responses. It is a potent inhibitor of serotonin reuptake, leading to prolonged activity of serotonin in synaptic spaces.
Indications for Use:
Clofranil tablets are specifically indicated for the management of obsessive-compulsive disorder (OCD) and major depressive disorder. They are recommended for individuals requiring pharmacological intervention to alleviate symptoms associated with these conditions.
Contraindications:
It is contraindicated to use Clofranil if there is a known history of hypersensitivity to Clomipramine or other tricyclic antidepressants. Patients with such hypersensitivity reactions should avoid the use of this medication.
Side Effects:
Common side effects associated with Clofranil may include drowsiness, dizziness, dry mouth, constipation, blurred vision, and weight gain. Patients should promptly report any adverse reactions to their healthcare provider.
Usage Instructions:
The typical initial dosage of Clofranil is 25 mg per day, with gradual increments as prescribed by a healthcare professional. It is generally recommended to take the tablets orally, either with or without food, once daily at bedtime.
Benefits Compared to Analogues:
Clofranil offers distinct advantages over other antidepressants in its class due to its potent serotonin reuptake inhibition properties, which contribute to its efficacy in managing OCD and major depressive disorder. Its established clinical effectiveness and tolerability profile make it a preferred choice for many healthcare providers.
Suitable Patient Groups:
Clofranil can be utilized in various patient populations, including adults, elderly individuals, and certain pediatric cases under close medical supervision. Dosage adjustments may be necessary based on individual patient characteristics and health status.
Storage Conditions and Shelf Life:
It is advised to store Clofranil tablets at room temperature, away from light and moisture, to maintain their stability and efficacy. The shelf life of the product should be checked, and expired tablets should not be used.
Packaging Description:
Clofranil is available in blister packs containing 50 coated tablets, each tablet encapsulating 25 mg of Clomipramine hydrochloride. The packaging is designed to ensure product integrity and protection from external factors.
Clinical Evidence and Proven Effectiveness:
Several studies have validated the efficacy of Clomipramine in treating OCD. Notably, a meta-analysis published in the Journal of Clinical Psychopharmacology demonstrated the superior efficacy of Clomipramine compared to a placebo in reducing OCD symptoms. Furthermore, a study in the Journal of Clinical Psychiatry highlighted the long-term effectiveness and tolerability of Clomipramine in managing OCD symptoms.
Additional Information:
- Warnings: Clofranil may induce drowsiness or dizziness. Caution is advised when engaging in activities requiring mental alertness, such as driving or operating machinery.
- Storage: Keep Clofranil tablets at room temperature in a dry place shielded from light and moisture to preserve their quality.
- Pregnancy: Consult a healthcare provider before using Clofranil if pregnant or planning pregnancy to assess the potential risks and benefits for both the mother and the developing fetus.
