Description

Closart (Losartan) Coated Tablets 50 mg. №84

Composition

Active ingredient: Losartan potassium 50 mg.

Other ingredients: Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, macrogol, titanium dioxide (E171).

Mechanism of Action

Losartan, an angiotensin II receptor blocker (ARB), reduces blood pressure by blocking the effects of angiotensin II, leading to vasodilation and decreased aldosterone secretion.

Pharmacological Properties

Losartan acts selectively on the AT1 receptor subtype. It inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, resulting in decreased blood pressure.

Indications for Use

Closart (Losartan) coated tablets 50 mg. №84 are indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older to lower blood pressure.

Contraindications

Avoid Closart (Losartan) coated tablets 50 mg. №84 if allergic to losartan or any other ingredients. Not recommended during pregnancy due to potential harm to the unborn baby.

Side Effects

Common side effects may include dizziness, hypotension, hyperkalemia, and renal impairment. Consult a healthcare provider for a full list of side effects.

Usage Instructions

Take one tablet orally daily, or as directed by a healthcare professional. Swallow the tablet whole with a glass of water. Do not exceed the recommended dose.

Benefits Compared to Analogues

Losartan has shown similar efficacy to ACE inhibitors and beta-blockers in lowering blood pressure, with potentially fewer side effects, making it a valuable option in hypertension management.

Suitable Patient Groups

Closart (Losartan) coated tablets 50 mg. №84 can be used in children (6 years and older) and the elderly under appropriate medical supervision.

Storage and Shelf Life

Store in a cool, dry place away from moisture and sunlight. Check the expiration date on the packaging and do not use beyond that date.

Packaging Description

Closart (Losartan) coated tablets 50 mg. №84 are packed in a blister pack containing 84 tablets. The packaging is designed to protect the tablets from environmental factors.

Clinical Evidence and Proven Effectiveness

Losartan has been extensively studied in clinical trials, demonstrating its efficacy in managing hypertension. Studies have shown that losartan effectively lowers blood pressure as a monotherapy or in combination with other antihypertensive agents.