Description

Contriven (aprotinin) solution for injections 10000C IU/ml. 5 ml. ampoules №5

Ingredients:

Each 5 ml ampoule contains 10000C IU/ml of aprotinin as the active ingredient.

Dosage:

The dosage of Contriven should be determined by a healthcare professional based on the individual’s condition and response to treatment. It is typically administered via injection.

Indications:

Contriven is indicated for the management of bleeding during complex surgery, particularly cardiac surgery. It works by inhibiting certain enzymes that break down fibrin clots, thereby reducing bleeding.

Contraindications:

Contriven is contraindicated in individuals with a history of hypersensitivity to aprotinin or any component of the formulation. It should not be used in patients with a history of anaphylaxis to aprotinin.

Directions:

Contriven should be administered by a healthcare professional in a hospital setting. The injection should be given slowly to minimize the risk of adverse reactions.

Scientific Evidence:

Contriven’s efficacy in reducing bleeding during cardiac surgery has been supported by several clinical trials. A study published in the *Journal of Thoracic and Cardiovascular Surgery* demonstrated that aprotinin significantly decreased blood loss and transfusion requirements compared to placebo in patients undergoing coronary artery bypass grafting.

Additional Information:

Contriven’s pharmacological action involves the inhibition of proteolytic enzymes, such as plasmin, that degrade fibrin clots. By preserving these clots, Contriven helps maintain hemostasis during surgery. Compared to other antifibrinolytic agents, aprotinin has shown to be more effective in certain high-risk surgical procedures, providing better outcomes for patients.

Contriven’s role in reducing bleeding and transfusion requirements in cardiac surgery has made it a valuable tool for surgeons. Its ability to improve patient outcomes by minimizing blood loss and related complications underscores its importance in modern surgical practice.