Description

Cordipin Retard (Nifedipine) Prolonged-Release Tablets 20 mg – Pack of 30 Tablets

Composition

Active Ingredient: Each tablet contains 20 mg of nifedipine. Other ingredients include lactose, cellulose, and magnesium stearate.

Mechanism of Action

Nifedipine, a calcium channel blocker, inhibits calcium influx into vascular smooth muscle cells, leading to vasodilation and decreased peripheral vascular resistance. This results in reduced myocardial oxygen demand and improved coronary blood flow.

Pharmacological Properties

Nifedipine exerts its antihypertensive and antianginal effects by selectively blocking calcium channels in vascular smooth muscle cells, leading to relaxation of coronary and peripheral arteries, decreased systemic vascular resistance, and improved oxygen delivery to the heart.

Indications

Cordipin Retard tablets are indicated for the management of hypertension and chronic stable angina. They aid in vasodilation, reducing blood pressure, and enhancing myocardial oxygen supply by decreasing cardiac workload.

Contraindications

Avoid using Cordipin Retard tablets if you have hypotension, a history of myocardial infarction, or hypersensitivity to nifedipine. Pregnant or lactating individuals should seek medical advice before initiating treatment.

Side Effects

Common side effects may include headache, dizziness, flushing, peripheral edema, and palpitations. Severe adverse reactions such as hypotension, tachycardia, and allergic reactions are rare but possible.

Usage Instructions

Take one Cordipin Retard tablet every 12 hours as directed by a healthcare professional. Swallow the tablet whole with water and avoid grapefruit or grapefruit juice consumption during treatment.

Benefits Compared to Analogues

Cordipin Retard offers the advantage of convenient dosing with prolonged-release formulation, ensuring sustained therapeutic blood levels and improved patient compliance compared to immediate-release formulations of nifedipine.

Suitable Patient Groups

Cordipin Retard is suitable for adult patients with hypertension or chronic stable angina. Dosage adjustments may be necessary for elderly individuals or those with hepatic impairment. Pediatric use is not recommended.

Storage and Shelf Life

Store Cordipin Retard tablets in a cool, dry place away from direct sunlight. Check the packaging for the expiration date and do not use the product beyond the stated shelf life.

Packaging Description

Cordipin Retard tablets are supplied in packs containing 30 tablets with prolonged-release formulation. The packaging is designed to maintain product integrity and protect the tablets from environmental factors.

Clinical Evidence and Proven Effectiveness

Nifedipine’s efficacy in managing hypertension and angina is supported by clinical studies. Research in the Journal of Clinical Hypertension demonstrated nifedipine’s ability to lower blood pressure and reduce angina attacks frequency. Additionally, a study in the American Journal of Cardiology highlighted nifedipine’s tolerability and significant blood pressure reduction in essential hypertension patients.