Description

Coriol (carvedilol) tablets 6.25 mg. №28

Ingredients

Active ingredient: Carvedilol 6.25 mg per tablet.

Dosage

Dosage: The usual starting dose is one 6.25 mg tablet twice daily. Dosage may be increased gradually.

Indications

Indications: Coriol tablets are indicated for the treatment of hypertension, heart failure, and left ventricular dysfunction following myocardial infarction.

Contraindications

Contraindications: Do not use Coriol tablets if you have bronchial asthma, certain heart conditions, severe liver impairment, or are allergic to carvedilol.

Directions

Directions: Take Coriol tablets by mouth with food. Do not crush or chew the tablets. Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence

Carvedilol, the active ingredient in Coriol tablets, is a non-selective beta-blocker with additional alpha-blocking properties. It has been extensively studied in various clinical trials for its efficacy in managing hypertension and heart failure. Research has shown that carvedilol reduces cardiovascular mortality and hospitalizations in patients with heart failure. Additionally, it has been found to improve left ventricular function and decrease blood pressure effectively.

Additional Information

Coriol tablets should be stored at room temperature away from moisture and heat. Keep this medication out of reach of children. It is important to attend regular follow-up appointments with your healthcare provider while taking Coriol to monitor your response to the treatment.

Pharmacological Effects: Carvedilol works by blocking beta receptors in the heart and blood vessels, leading to a decrease in heart rate and blood pressure. It also dilates blood vessels through its alpha-blocking activity, improving blood flow and reducing the workload on the heart.

Clinical Trials: A study published in the New England Journal of Medicine demonstrated that carvedilol significantly reduced the risk of death or hospitalization in patients with heart failure compared to a placebo. Another study in the Journal of Hypertension showed that carvedilol effectively lowered blood pressure in hypertensive patients.