Description

Corvazan (carvedilol) Coated Tablets 12.5 mg. №30

Ingredients

Active ingredient: Carvedilol 12.5 mg.
Other ingredients: lactose monohydrate, crospovidone, povidone, colloidal anhydrous silica, magnesium stearate, hypromellose, macrogol 400, titanium dioxide (E171).

Dosage

Recommended dosage: The usual starting dose is 12.5 mg once daily for the first two days. The dose may then be increased to 25 mg once daily.

Indications

Corvazan (carvedilol) tablets are indicated for the treatment of hypertension, heart failure, and left ventricular dysfunction following myocardial infarction.

Contraindications

Do not use Corvazan tablets if: you have bronchial asthma or related bronchospastic conditions, severe bradycardia, heart block greater than first degree, cardiogenic shock, or decompensated heart failure requiring IV inotropic therapy.

Directions

Take Corvazan tablets orally with food. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Carvedilol, the active ingredient in Corvazan tablets, is a non-selective beta-blocker with additional alpha-blocking properties. It has been shown to reduce morbidity and mortality in patients with heart failure and left ventricular dysfunction. Studies like the COPERNICUS trial have demonstrated the efficacy of carvedilol in improving symptoms and outcomes in heart failure patients.

Additional Information

It is important to monitor blood pressure and heart rate regularly while taking Corvazan tablets. Inform your healthcare provider about any other medications you are taking to avoid potential drug interactions. In case of any adverse reactions or concerns, seek medical advice promptly.

Carvedilol works by blocking the action of certain natural substances in the body, such as epinephrine, on the heart and blood vessels. This results in lowered heart rate, blood pressure, and strain on the heart, thereby improving its function. Additionally, carvedilol’s antioxidant properties may play a role in protecting the heart from further damage.

Compared to other beta-blockers, carvedilol has shown to be effective in a broader range of cardiovascular conditions due to its unique pharmacological profile. Its combination of beta and alpha-blocking properties sets it apart in the management of hypertension and heart failure, making it a valuable option in clinical practice.