Description

Depakin Chrono (sodium valproate) Coated Tablets with Prolonged Release 300 mg. №100

Ingredients:

Each coated tablet contains 300 mg of sodium valproate.

Dosage:

The usual starting dose is 600 mg per day, divided into two doses. The dosage may be adjusted based on individual response.

Indications:

Depakin Chrono is indicated for the treatment of epilepsy and bipolar disorder. It helps control seizures and stabilize mood swings.

Contraindications:

Do not use Depakin Chrono if you are allergic to sodium valproate or any other ingredients in the tablets. It is contraindicated in patients with liver disease or urea cycle disorders.

Directions:

Swallow the tablets whole with a glass of water. Do not crush or chew them. Take the medication with food to reduce stomach upset.

Scientific Evidence:

Depakin Chrono, containing sodium valproate, has been extensively studied for its efficacy in managing epilepsy and bipolar disorder. Research published in the *Journal of Clinical Psychopharmacology* demonstrated the effectiveness of sodium valproate in reducing the frequency and severity of seizures in patients with epilepsy.

Additional Information:

It is essential to monitor liver function tests regularly while taking Depakin Chrono, as sodium valproate can affect liver enzymes. Consult your healthcare provider if you experience any unusual symptoms while on this medication.

Pharmacological Effects: Sodium valproate works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, which is a neurotransmitter that helps calm excessive electrical nerve activity. This action helps in controlling seizures and stabilizing mood in bipolar disorder.

Clinical Trials: A randomized controlled trial published in the *Journal of Neurology, Neurosurgery & Psychiatry* compared the efficacy of sodium valproate with other antiepileptic drugs. The study concluded that sodium valproate was equally effective in seizure control and had a favorable side effect profile.