Diacarb (acetazolamide) tablets 250 mg. №30

Description

Treatment of glaucoma: chronic open-angle glaucoma secondary glaucoma glaucoma (for short-term preoperative therapy and before ophthalmological procedures, to reduce intraocular pressure). Treatment of edema: in heart failure edema caused by taking medications. Treatment of epilepsy (in combination with other anticonvulsants): etit mal (small seizures) in children grand mal (large seizures) in adults, the mixed form. Treatment of altitude sickness (the drug reduces the time of acclimatization, but its effect on the manifestations of this disease is insignificant). Contraindications. Hypersensitivity to the drug components and sulfonamides, impaired liver and kidney function, acute renal failure, liver failure, hyponatremia and / or hypokalemia, Addison’s disease, adrenal insufficiency, hyperchloremic acidosis. Acetazolamide is contraindicated in patients with cirrhosis of the liver, as this may increase the risk of hepatic encephalopathy. Long-term use of acetazolamide is contraindicated in patients with chronic decompensated angle-closure glaucoma, since in the case of complete closure of the angle of the eye chamber, the deterioration of glaucoma will be masked by reduced intraocular pressure. Urolithiasis (hypercalciuria), diabetes mellitus, uremia. Interaction with other drugs and other types of interactions. Acetazolamide may increase the effects of folic acid antagonists, hypoglycemic agents and anticoagulants, which is taken orally. Simultaneous use of acetazolamide with acetylsalicylic acid can lead to severe acidosis and toxic effects on the Central nervous system with the risk of anorexia, tachypnea, lethargy, coma with a possible fatal outcome. If acetazolamide is used simultaneously with cardiac glycosides or drugs that increase blood pressure, the dose of the former must be changed. Acetazolamide disrupts the metabolism of phenytoin, increasing the concentration of the latter in the blood serum. In patients taking acetazolamide with certain PSP (phenytoin, primidone), a severe form of osteomalacia was observed. Simultaneous use of acetazolamide with amphetamines, atropine or quinidine may increase their side effects. The excretion of amphetamine and quinidine is reduced, so it is possible to increase the time of action of amphetamine and enhance the action of quinidine by increasing the pH of urine in the renal tubules. Acetazolamide can increase or decrease the concentration of glucose in the blood, which should be taken into account in the treatment of diabetes. You may need to change the dose of insulin or oral hypoglycemic medications. Acetazolamide increases the excretion of lithium and can reduce the level of lithium in the blood plasma. Acetazolamide may increase the concentration of carbamazepine in blood plasma. When used simultaneously, acetazolamide increases the risk of toxic effects of salicylates, digitalis preparations, carbamazepine, ephedrine, and non-depolarizing muscle relaxants. The diuretic effect of acetazolamide is enhanced by theophylline, weakened by acid-producing diuretics. Were few reports on the decrease in the level of primidone in serum and increasing the level of carbamazepine during their concomitant use with acetazolamide. Due to possible additive effects, simultaneous use with other carbonic anhydrase inhibitors is not recommended. Cyclosporine: acetazolamide may increase cyclosporine levels. Methenamine: acetazolamide may interfere with the antiseptic effect of Methenamine in the urine. Sodium bicarbonate: the simultaneous use of acetazolamide with sodium bicarbonate increases the risk of formation of renal calculi.