Description

Dicloberl-100 (diclofenac sodium) suppositories 100 mg. №10

Ingredients:

Active ingredient: Diclofenac sodium 100 mg per suppository.

Dosage:

Adults: The usual dose is one suppository inserted into the rectum once daily.

Indications:

Dicloberl-100 suppositories are indicated for the relief of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Contraindications:

Do not use Dicloberl-100 suppositories if you have a history of allergic reactions to diclofenac or other NSAIDs, or if you have active peptic ulcers.

Directions:

For rectal use only. Wash hands before and after use. Lie on your side and insert the suppository into the rectum. Follow the instructions provided by your healthcare provider.

Scientific Evidence:

Diclofenac, the active ingredient in Dicloberl-100 suppositories, is a potent nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins involved in inflammation and pain. Studies have shown diclofenac to be effective in managing various painful conditions, with rectal administration providing a rapid onset of action.

Additional Information:

Dicloberl-100 suppositories offer a convenient and effective way to deliver diclofenac for individuals who may have difficulty swallowing tablets or capsules. It is important to follow the recommended dosage and precautions to minimize the risk of adverse effects. Consult your healthcare provider for personalized advice on the use of this medication.

Pharmacological studies have demonstrated the efficacy of diclofenac in providing analgesic and anti-inflammatory effects by targeting key mediators of pain and inflammation. Clinical trials have shown diclofenac to be comparable in effectiveness to other NSAIDs, making it a valuable option for the management of various musculoskeletal conditions.

Research published in the Journal of Pain Research has highlighted the role of diclofenac in improving pain scores and functional outcomes in patients with osteoarthritis, further supporting its use as a first-line treatment in the management of chronic joint pain.