Description

Diflazon (Fluconazole) Capsules 50 mg. №7

Ingredients

Active ingredient: Fluconazole 50 mg.
Inactive ingredients: Lactose, maize starch, colloidal anhydrous silica, magnesium stearate, sodium lauryl sulfate, gelatin, titanium dioxide (E171), brilliant blue FCF (E133), erythrosine (E127).

Dosage

Dosage: The usual dose is one capsule daily. Consult your healthcare provider for the correct dosage based on your condition.

Indications

Indications: Diflazon is indicated for the treatment of fungal infections including vaginal yeast infections, oral thrush, esophageal candidiasis, and cryptococcal meningitis.

Contraindications

Contraindications: Do not use Diflazon if you are allergic to fluconazole or other azole antifungal drugs.

Directions

Directions: Take Diflazon as directed by your healthcare provider. Swallow the capsule whole with a full glass of water. Do not crush or chew the capsule.

Scientific Evidence

Fluconazole, the active ingredient in Diflazon, is a potent antifungal agent that works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. Several studies have demonstrated the efficacy of fluconazole in treating various fungal infections, with high cure rates and minimal side effects.

Additional Information

It is important to complete the full course of treatment with Diflazon as prescribed by your healthcare provider, even if your symptoms improve before the medication is finished. Abruptly stopping the medication can lead to the recurrence of the infection.

Pharmacological Effects

Fluconazole exerts its antifungal effects by selectively inhibiting the enzyme lanosterol 14-alpha-demethylase involved in the biosynthesis of ergosterol, a vital component of fungal cell membranes. By disrupting ergosterol synthesis, fluconazole compromises the structural integrity of fungal cells, leading to their death. This targeted mechanism of action makes fluconazole highly effective against a wide range of fungal pathogens.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown fluconazole to be highly effective in the treatment of various fungal infections, often achieving cure rates comparable to or better than other antifungal agents. In comparative studies, fluconazole has demonstrated superior efficacy in the treatment of vaginal candidiasis and invasive candidiasis, highlighting its role as a first-line therapy for these conditions.

References:
1. Perfect JR. “Treatment of Candidiasis.” In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Churchill Livingstone; 2015.
2. Pappas PG, Kauffman CA, Andes DR, et al. “Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.” Clin Infect Dis. 2016;62(4):e1-e50.