Description
Diflazon (Fluconazole) Solution for Infusions 2 mg/ml. 100 ml. №1 Vial
Ingredients:
Each ml contains 2 mg of fluconazole as the active ingredient.
Mechanism of Action:
Fluconazole, the active ingredient in Diflazon, is a potent antifungal agent that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This disruption leads to the destabilization of the fungal cell membrane, ultimately causing cell death.
Pharmacological Properties:
Fluconazole exhibits fungistatic activity by interfering with the synthesis of ergosterol, essential for fungal cell membrane integrity. It is well-absorbed after intravenous administration and demonstrates excellent tissue penetration, including the central nervous system.
Indications for Use:
Diflazon solution is indicated for the treatment of various fungal infections, including candidiasis, cryptococcal meningitis, and other systemic fungal infections. It is effective in both immunocompromised and non-immunocompromised patients.
Contraindications:
Do not use Diflazon if you have a known hypersensitivity to fluconazole or other azole antifungal agents. It is contraindicated in patients with a history of allergic reactions to the drug.
Side Effects:
Common side effects of Diflazon may include nausea, headache, and rash. These side effects are typically mild and transient. However, it is essential to monitor for signs of liver dysfunction, as hepatotoxicity may occur in some individuals.
Usage Instructions:
The recommended dosage of Diflazon should be determined by the treating physician based on the specific fungal infection being treated. It is usually administered intravenously over a prescribed period. The solution should be prepared for infusion following the manufacturer’s instructions.
Benefits Compared to Analogues:
Diflazon offers a broad spectrum of antifungal activity with a favorable safety profile. Its convenient dosing regimen and efficacy in the management of invasive fungal infections make it a preferred choice over other antifungal agents.
Suitable Patient Groups:
Diflazon can be used in various patient populations, including children and the elderly, under appropriate medical supervision. Dosage adjustments may be necessary based on individual patient characteristics.
Storage and Shelf Life:
Diflazon should be stored according to the manufacturer’s recommendations to maintain its stability and efficacy. It is essential to check the expiration date on the packaging and avoid using expired products.
Packaging Description:
Diflazon is available in vials containing 100 ml of 2 mg/ml solution for intravenous infusions. Each vial is intended for single-use only and should be handled and disposed of properly according to medical waste disposal guidelines.
Clinical Evidence and Proven Effectiveness:
Clinical studies have demonstrated the efficacy of Diflazon in treating invasive candidiasis and other systemic fungal infections. The broad spectrum of antifungal activity and the well-established safety profile of fluconazole make Diflazon a valuable option in the management of fungal infections.
