Description

Difliuzol (fluconazole) capsules 0.1g. №7

Ingredients

Active ingredient: Fluconazole 0.1g per capsule.

Dosage

Dosage: The usual dose of Difliuzol (fluconazole) is 150 mg as a single oral dose.

Indications

Indications: Difliuzol (fluconazole) is indicated for the treatment of various fungal infections, including vaginal yeast infections, oral thrush, esophageal candidiasis, and cryptococcal meningitis.

Contraindications

Contraindications: Do not use Difliuzol (fluconazole) if you are allergic to fluconazole or other azole antifungal drugs.

Directions

Directions: Take Difliuzol (fluconazole) capsules orally with or without food as directed by your healthcare provider.

Scientific Evidence

Fluconazole, the active ingredient in Difliuzol, is a potent antifungal agent that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. Several studies have demonstrated the efficacy of fluconazole in treating various fungal infections, with high cure rates and minimal side effects.

Additional Information

It is important to complete the full course of treatment with Difliuzol (fluconazole) as prescribed by your healthcare provider to ensure the infection is fully eradicated. If you experience any severe side effects or allergic reactions, discontinue use and seek medical attention immediately.

Pharmacological Effects: Fluconazole exerts its antifungal effects by selectively inhibiting fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase, which is essential for the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased permeability and leakage of essential cellular components, ultimately causing fungal cell death.

Clinical Trials: Clinical trials have shown that fluconazole is highly effective in the treatment of various fungal infections, with comparable or superior efficacy to other antifungal agents. In a study by Pappas et al., fluconazole was found to be as effective as amphotericin B in the treatment of candidemia and other invasive Candida infections, with a more favorable side effect profile.