Description

Difliuzol (Fluconazole) Solution for Infusions 2 mg/ml. 100 ml. №1 Vial

Ingredients:

Each ml contains 2 mg of fluconazole as the active ingredient.

Dosage:

The recommended dosage is determined by the treating physician based on the patient’s condition. It is usually administered intravenously over a specific period.

Indications:

Difliuzol is indicated for the treatment of invasive candidiasis, cryptococcal meningitis, and other fungal infections. It is also used for prophylaxis in patients at high risk for fungal infections.

Contraindications:

Do not use Difliuzol in patients with known hypersensitivity to fluconazole or other azole antifungal agents. It should be used with caution in patients with liver or kidney impairment.

Directions:

Administer the solution intravenously as directed by a healthcare professional. Follow the specific instructions provided with the product.

Scientific Evidence:

Fluconazole, the active ingredient in Difliuzol, is a well-established antifungal agent with proven efficacy in the treatment of various fungal infections. Studies have shown its effectiveness in treating candidiasis, cryptococcal meningitis, and other fungal diseases. Research published in the Journal of Antimicrobial Chemotherapy demonstrated the high efficacy of fluconazole in the treatment of invasive candidiasis, highlighting its role as a first-line therapy in such infections.

Additional Information:

In clinical trials, Difliuzol has shown to be well-tolerated with a favorable safety profile. It is important to monitor liver function tests during treatment, especially in patients with pre-existing liver conditions. Consult with a healthcare provider for personalized dosing and monitoring while using Difliuzol.

Pharmacological Effects: Fluconazole works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This disrupts the integrity of the fungal cell wall, leading to cell death. The specificity of fluconazole for fungal cells minimizes its impact on human cells, reducing the risk of adverse effects.

Comparative Effectiveness: Compared to other antifungal agents, fluconazole is known for its broad spectrum of activity against various fungal species. Its ability to penetrate well into tissues and fluids makes it a valuable option for the treatment of systemic fungal infections. Additionally, its convenient dosing regimen and established safety profile contribute to its widespread use in clinical practice.