Description

Digoxin (digoxin) tablets 0.25 mg. №50

Ingredients

Active ingredient: Digoxin 0.25 mg per tablet.

Dosage

Dosage: The usual maintenance dose is 0.125-0.25 mg once daily. Dosage may vary based on individual patient needs and response.

Indications

Indications: Digoxin is indicated for the treatment of heart failure and atrial fibrillation.

Contraindications

Contraindications: Do not use Digoxin in patients with ventricular fibrillation. Use with caution in patients with certain heart conditions.

Directions

Directions: Take Digoxin exactly as prescribed by your healthcare provider. Do not exceed the recommended dose.

Scientific Evidence

Digoxin, a cardiac glycoside, works by inhibiting the sodium-potassium ATPase pump, leading to increased intracellular calcium levels. This results in enhanced myocardial contractility and improved cardiac output in heart failure. Studies have shown that Digoxin reduces hospitalizations and improves symptoms in patients with heart failure (Ahmed et al., 2006).

Additional Information

It is important to monitor serum digoxin levels regularly to ensure therapeutic levels are maintained. Patients should be educated on the signs of digoxin toxicity, such as nausea, vomiting, and visual disturbances. In case of overdose, seek immediate medical attention.

Pharmacological Effects

Digoxin’s pharmacological action involves its ability to increase the force of myocardial contraction, slow the heart rate, and reduce conduction velocity through the atrioventricular node. These effects make it a valuable medication in the management of heart failure and certain arrhythmias.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of Digoxin in improving symptoms and reducing hospitalizations in patients with heart failure when used in conjunction with standard therapies (Digitalis Investigation Group, 1997). Comparative studies have shown Digoxin to be equally effective or superior to other heart failure medications in certain patient populations.

References:
– Ahmed A, Rich MW, Fleg JL, et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial. Circulation. 2006;114(5):397-403.
– Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997;336(8):525-533.