Description

Dimaril (Glimepiride) Tablets 2 mg. №30

Ingredients

Active ingredient: Glimepiride 2 mg

Inactive ingredients: Lactose monohydrate, microcrystalline cellulose, magnesium stearate, and others.

Mechanism of Action

Glimepiride, a sulfonylurea, stimulates insulin release from pancreatic beta cells, leading to decreased blood glucose levels in patients with type 2 diabetes mellitus.

Pharmacological Properties

Glimepiride exerts its antidiabetic effects by binding to ATP-sensitive potassium channels on pancreatic beta cells, causing depolarization and subsequent insulin secretion.

Indications for Use

Indications: Dimaril (Glimepiride) is indicated for the management of type 2 diabetes mellitus when dietary modifications, physical activity, and weight loss fail to control blood glucose levels adequately.

Contraindications

Contraindications: Dimaril (Glimepiride) should not be administered to individuals with a history of hypersensitivity to sulfonylureas or any components of the formulation.

Side Effects

Common side effects of Dimaril (Glimepiride) include dizziness, headache, and nausea. Patients should seek medical advice if they experience severe or persistent adverse reactions.

Usage Instructions

Dosage: The typical initial dose is 1-2 mg once daily with breakfast or the first main meal. Adjustments to the dosage should be based on individual blood glucose levels.

Directions: Patients should adhere to the prescribed Dimaril (Glimepiride) regimen without altering the dose or discontinuing treatment without consulting a healthcare professional.

Benefits Compared to Analogues

Dimaril (Glimepiride) offers comparable efficacy to other sulfonylureas in managing type 2 diabetes mellitus while potentially posing a lower risk of hypoglycemia due to its shorter duration of action.

Suitable Patient Groups

Dimaril (Glimepiride) is suitable for adult patients with type 2 diabetes mellitus, including the elderly population. However, caution should be exercised in patients with hepatic or renal impairment.

Storage and Shelf Life

• Storage: Dimaril (Glimepiride) tablets should be stored at room temperature, shielded from moisture and heat sources.
• Shelf Life: Check the product packaging for the expiration date and do not use expired medication.

Packaging Description

The product packaging contains 30 tablets of Dimaril (Glimepiride) 2 mg each, securely sealed to maintain product integrity and potency.

Clinical Evidence and Proven Effectiveness

Studies have demonstrated that Glimepiride effectively reduces HbA1c levels and enhances glycemic control in patients with type 2 diabetes mellitus. Research published in the Journal of Diabetes Research revealed that Glimepiride, either as monotherapy or in combination with other antidiabetic agents, significantly lowered fasting plasma glucose levels and improved overall glucose regulation compared to a placebo group.