Description

Dimaril (Glimepiride) Tablets 2 mg. №60

Ingredients

Active ingredient: Glimepiride 2 mg.

Inactive ingredients: Lactose monohydrate, microcrystalline cellulose, povidone, sodium starch glycolate, and magnesium stearate.

Mechanism of Action

Glimepiride, a sulfonylurea, stimulates insulin release from pancreatic beta cells and enhances peripheral insulin sensitivity.

Pharmacological Properties

Glimepiride increases insulin secretion from the pancreas, reducing blood glucose levels. It also enhances insulin sensitivity in peripheral tissues, improving glucose utilization.

Indications for Use

Dimaril tablets are prescribed for type 2 diabetes mellitus management when diet, exercise, and weight loss are insufficient.

Contraindications

Do not use Dimaril (Glimepiride) tablets 2 mg. №60 in:

• Patients with hypersensitivity to glimepiride or other sulfonylureas
• Individuals with type 1 diabetes or diabetic ketoacidosis
• Pregnant or lactating women

Side Effects

Common side effects may include hypoglycemia, nausea, and dizziness. Serious but rare side effects can include severe allergic reactions.

Usage Instructions

Dosage: The initial dose is usually 1-2 mg once daily with breakfast or the first main meal. Adjustments are based on blood glucose levels.

Administration: Swallow the tablet whole with water. Typically taken once daily with a meal.

Benefits Compared to Analogues

Dimaril has shown efficacy in managing blood glucose levels and improving glycemic control, with a favorable safety profile compared to other antidiabetic agents.

Suitable Patient Groups

Dimaril is suitable for adult patients with type 2 diabetes. Dosage adjustments may be necessary for elderly individuals or those with renal impairment.

Storage and Shelf Life

Store Dimaril tablets in a cool, dry place away from moisture and sunlight. Check the expiry date on the packaging and do not use expired medication.

Packaging Description

Dimaril tablets are available in packs of 60 tablets, each containing 2 mg of glimepiride. The packaging should be kept intact until the tablets are consumed.

Clinical Evidence and Proven Effectiveness

Glimepiride has demonstrated efficacy in reducing blood glucose levels and enhancing glycemic control in type 2 diabetes patients. Clinical trials, such as the study by Schernthaner et al. (2007), have shown non-inferiority of glimepiride compared to other antidiabetic agents in terms of efficacy and safety.