Description
Doxorubicin (Doxorubicin) Concentrate for Infusions 2 mg/ml, 5 ml (10 mg) Vial No.1
Ingredients:
Each milliliter contains 2 mg of Doxorubicin hydrochloride.
Mechanism of Action:
Doxorubicin works by intercalating into DNA strands, inhibiting cell replication, and inducing cell death. It also produces free radicals that cause DNA damage in cancer cells, enhancing their destruction.
Pharmacological Properties:
Doxorubicin is a cytotoxic anthracycline antibiotic that exerts its antitumor effects by disrupting DNA function in cancer cells. It has broad-spectrum activity against various malignancies.
Indications for Use:
Doxorubicin is indicated for the treatment of multiple cancers, such as breast cancer, lung cancer, and leukemia. It is effective in halting the proliferation of malignant cells.
Contraindications:
Doxorubicin is contraindicated in individuals with severe cardiac issues, hepatic disorders, or a history of hypersensitivity reactions to Doxorubicin. Its use is not recommended during pregnancy due to potential risks to the fetus.
Side Effects:
Common side effects of Doxorubicin include temporary hair loss, nausea, and potential cardiotoxicity. Regular monitoring of cardiac function is essential during treatment to detect and manage any cardiac-related complications.
Usage Instructions:
The dosage of Doxorubicin is personalized based on the patient’s health status, weight, and specific condition. It is administered intravenously by a qualified healthcare provider in a clinical setting.
Advantages Over Analogues:
Doxorubicin offers superior efficacy compared to many other chemotherapy agents, especially in combination regimens. Its broad antitumor spectrum and established clinical effectiveness make it a cornerstone in cancer therapy.
Suitable Patient Groups:
Doxorubicin can be used in various patient populations, including adults, elderly individuals, and pediatric patients, under appropriate medical supervision and dosing adjustments.
Storage and Shelf Life:
Doxorubicin should be stored as per the manufacturer’s instructions, typically at controlled room temperature. The shelf life of the product is specified on the packaging and should be strictly adhered to.
Packaging Description:
Doxorubicin is supplied in vials containing 5 ml of concentrate for infusion, with each vial providing 10 mg of the active ingredient. The packaging is designed to maintain product stability and sterility.
Clinical Evidence and Effectiveness:
Research studies have demonstrated the efficacy of Doxorubicin in treating a wide range of malignancies. Notably, a study in the Journal of Clinical Oncology highlighted the survival benefits of Doxorubicin in combination with other chemotherapeutic agents for advanced cancer patients.
