Description
Ecvoral (Cyclosporine) Capsules 50 mg. №50
Composition
Active Ingredient: Cyclosporine
Other ingredients: Refer to the product packaging or insert for a full list of ingredients.
Mechanism of Action
Cyclosporine acts as an immunosuppressant by inhibiting the production of cytokines and interleukins, thereby preventing T-cell activation and the inflammatory response. This mechanism helps in reducing the risk of organ rejection in transplant patients and controlling autoimmune reactions in conditions like rheumatoid arthritis and psoriasis.
Pharmacological Properties
Cyclosporine is a calcineurin inhibitor that selectively inhibits the transcription of genes involved in the immune response. It exhibits high tissue distribution with a half-life of approximately 6-12 hours, making it suitable for twice-daily dosing. The drug is extensively metabolized in the liver and excreted mainly through bile.
Indications for Use
Cyclosporine is indicated for:
- Preventing organ rejection in transplant recipients
- Treating autoimmune diseases such as rheumatoid arthritis and psoriasis
Contraindications
Do not use Cyclosporine if:
- You are allergic to cyclosporine or any of the other ingredients
- You have uncontrolled high blood pressure
- You are pregnant or breastfeeding
Side Effects
Common side effects of Cyclosporine may include hypertension, renal dysfunction, tremors, hypertrichosis, and gastrointestinal disturbances. Regular monitoring of blood pressure, renal function, and serum drug levels is essential to manage these potential adverse effects.
Usage Instructions
Dosage: The usual recommended dose is 50 mg taken orally twice daily. Administer the capsules whole with a full glass of water. Do not crush or chew the capsules.
Benefits Compared to Analogues
Cyclosporine offers advantages over other immunosuppressants due to its targeted mechanism of action and lower incidence of adverse effects. Its efficacy in preventing organ rejection and managing autoimmune conditions has been well-established, making it a preferred choice for many healthcare providers.
Suitable Patient Groups
Cyclosporine is suitable for use in both adult and pediatric transplant recipients and patients with autoimmune diseases. Special caution is advised when prescribing to elderly individuals and those with pre-existing renal impairment, necessitating dose adjustments and close monitoring.
Storage and Shelf Life
Store Cyclosporine capsules in a cool, dry place away from direct sunlight. Ensure proper sealing of the packaging to protect from moisture. Check the expiry date on the packaging and do not use the product beyond the stated shelf life.
Packaging Description
Cyclosporine capsules are typically packaged in blister packs or amber glass bottles to maintain product stability and protect from light exposure. Each pack contains 50 capsules of 50 mg strength.
Clinical Evidence and Proven Effectiveness
Clinical studies have shown that Cyclosporine effectively reduces the incidence of acute rejection episodes in transplant patients and improves long-term graft survival rates. In autoimmune diseases, the drug demonstrates significant efficacy in controlling disease activity and reducing symptoms, enhancing patient quality of life.
