Description

Eglonil (sulpiride) Ampoules 100 mg. 2 ml. №6

Ingredients

Active ingredient: Sulpiride
Other ingredients: Mannitol, sodium hydroxide, and water for injections.

Dosage

Dosage: The usual dose is 100-200 mg per day, divided into 2-3 doses.
Administration: Administer intramuscularly or intravenously.

Indications

Indicated for: Psychotic disorders, schizophrenia, and depressive states with anxiety.

Contraindications

• Contraindicated: Hypersensitivity to sulpiride, severe renal or hepatic impairment, and pheochromocytoma.
• Caution: Patients with a history of seizures, Parkinson’s disease, and elderly patients.

Directions

Storage: Store below 25°C. Protect from light.
Shelf life: Do not use after the expiry date.

Scientific Evidence

Pharmacological Effects: Sulpiride is a selective dopamine D2 receptor antagonist. It exerts antipsychotic effects by blocking dopamine receptors in the brain, particularly in the limbic system. This action helps alleviate symptoms of psychosis and schizophrenia.

Clinical Trials: Clinical studies have demonstrated the efficacy of sulpiride in treating various psychiatric disorders. A study by Xuan et al. (2018) showed that sulpiride was effective in reducing positive symptoms of schizophrenia compared to placebo.

Additional Information

Comparative Effectiveness: Sulpiride has shown comparable efficacy to other antipsychotic medications with a lower risk of extrapyramidal side effects. It is well-tolerated and suitable for long-term use in the management of psychotic disorders.

Safety Profile: Common side effects include gastrointestinal disturbances, dizziness, and extrapyramidal symptoms. Close monitoring is essential during treatment to ensure optimal therapeutic outcomes.