Description

Espa-carb (carbimazole) tablets 10 mg. №50

Ingredients

Active ingredient: Carbimazole 10 mg per tablet.

Dosage

Dosage: The usual starting dose is 15-40 mg daily in divided doses.

Indications

Indications: Espa-carb (carbimazole) is indicated for the treatment of hyperthyroidism, including Graves’ disease.

Contraindications

Contraindications: Do not use in patients with a history of hypersensitivity to carbimazole or other thionamide derivatives.

Directions

Directions: Take Espa-carb tablets orally with or without food as directed by your physician.

Scientific Evidence

Espa-carb (carbimazole) works by inhibiting the thyroid gland’s ability to produce thyroid hormones, thus helping to normalize hormone levels in hyperthyroidism. Studies have shown that carbimazole is effective in managing hyperthyroidism symptoms and improving thyroid function. Research published in the “Journal of Clinical Endocrinology & Metabolism” demonstrated the efficacy of carbimazole in reducing thyroid hormone levels in patients with Graves’ disease.

Additional Information

It is important to monitor thyroid function regularly while taking Espa-carb to ensure the appropriate dosage for each individual. Common side effects may include skin rash, itching, or gastrointestinal disturbances. Consult your healthcare provider if you experience any adverse reactions.

Pharmacological Effects: Carbimazole acts by inhibiting the enzyme thyroperoxidase, which is crucial for the synthesis of thyroid hormones. This action helps to reduce the production of excess thyroid hormones in hyperthyroidism.

Clinical Trials: In a comparative study published in the “European Journal of Endocrinology,” carbimazole was found to be as effective as propylthiouracil in the treatment of hyperthyroidism, with similar rates of adverse events reported in both treatment groups.