$19.00
Manufacturer: Ukraine
Local treatment of fungal infections caused by naftifin-sensitive pathogens: fungal infections of the skin and skin folds; interdigital mycoses; fungal nail infections (onychomycosis); skin candidiasis; pityriasis versicolor; inflammatory dermatomycosis, with or without itching; mycosis of the external auditory canal.
Description
Estezifin Pharmacological properties
Pharmacodynamics. estesifin is an antifungal agent of the allylamine class. its active ingredient is naftifine hydrochloride, the mechanism of action of which is associated with inhibition of the effect of ergosterol.
Naftifine is active against dermatophytes such as trichophyton, epidermophyton and microsporum, yeast (Candida), mold (Aspergillus) and other fungi (eg Sporothrix Schenckii). In relation to dermatophytes and aspergillus, naftifine in vitro has a fungicidal effect, in relation to yeasts, it exhibits a fungicidal or fungistatic effect, depending on the strain of the microorganism.
Estesifin also exhibits antibacterial activity against gram-positive and gram-negative microorganisms, which can cause secondary bacterial infections along with mycotic lesions.
In addition, Estesifin has anti-inflammatory properties, which helps to quickly eliminate the symptoms of inflammation and itching.
Estezifin Pharmacokinetics
Cream: naftifine hydrochloride is rapidly absorbed and forms stable antifungal concentrations in different layers of the skin. Approximately 4% of the dose applied to the skin is absorbed, therefore the systemic effect of the active substance is negligible. Only trace amounts of naftifine are detected in blood plasma and urine. The active substance is almost completely metabolized; metabolites have no antifungal activity and are excreted in feces and urine. Т½ is 2–4 days.
Spray, solution: due to the rapid penetration of the drug into the skin and the formation of persistent antifungal concentrations in different layers of the skin, Estesifin can be used once a day.
Estezifin Indications
Local treatment of fungal infections caused by pathogens sensitive to naftifine:
fungal infections of the skin and skin folds;
interdigital mycoses;
fungal infections of the nails (onychomycosis);
cutaneous candidiasis;
pityriasis versicolor;
inflammatory dermatomycosis, with or without itching;
mycosis of the external auditory canal (for solution).
Application
Estesifin should be applied to the affected skin area and adjacent areas 1 time per day after thorough cleaning and drying, capturing approximately 1 cm of healthy skin along the edges of the affected area.
Duration of treatment: with dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks); with candidiasis – 4 weeks; with nail infection – up to 6 months.
In case of fungal diseases of the nails, the drug is recommended to be used 2 times a day. Before the first use, it is necessary to remove the affected part of the nail as much as possible with scissors or a nail file (to facilitate this procedure, on the recommendation of a doctor, nails can be treated with a special softening agent).
To prevent relapses, drug treatment should be continued for at least 2 weeks after the disappearance of the main symptoms of the disease.
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